Özdem Furkan, Kaymak Sümeyya Duran, Turhan Berna, Hanedan Candost, Barlas Sezgi, Demirsoy Özge, Kavak Rasime Pelin
Department of Radiology, Health Sciences University Ankara Etlik City Hospital, Ankara, Turkey.
Department of Gynecologic Oncology, Health Sciences University Ankara Etlik City Hospital, Ankara, Turkey.
BMC Womens Health. 2025 May 2;25(1):213. doi: 10.1186/s12905-025-03755-7.
Ovarian mature cystic teratomas (MCTs) are the most prevalent benign ovarian tumors, with rare potential for malignant transformation, most commonly into squamous cell carcinoma. Accurate diagnosis is crucial for optimal management and prognosis.
A 27-year-old woman presented with a year-long history of intermittent abdominal and groin pain. Imaging studies, including contrast-enhanced computed tomography (CT) and magnetic resonance imaging (MRI), revealed a mixed solid-cystic lesion in the left adnexal region, consistent with an MCT exhibiting radiologic signs of malignancy. The patient underwent unilateral salpingo-oophorectomy, and intraoperative frozen section analysis suggested a mature cystic teratoma. However, definitive histopathological examination confirmed squamous cell carcinoma arising from the MCT. This case highlights the limitations of frozen section analysis in detecting malignancy.
Malignant transformation of MCTs, though rare, poses significant diagnostic and therapeutic challenges. Comprehensive preoperative imaging and meticulous postoperative histopathological evaluation are essential for accurate diagnosis and effective management. This case underscores the importance of interdisciplinary collaboration in addressing complex gynecologic pathologies.
卵巢成熟性囊性畸胎瘤（MCTs）是最常见的卵巢良性肿瘤，恶变潜能罕见，最常恶变为鳞状细胞癌。准确诊断对于最佳治疗和预后至关重要。
一名27岁女性，有长达一年的间歇性腹部和腹股沟疼痛病史。包括增强计算机断层扫描（CT）和磁共振成像（MRI）在内的影像学检查显示左附件区有一个混合实性囊性病变，符合表现出恶性放射学征象的MCT。患者接受了单侧输卵管卵巢切除术，术中冰冻切片分析提示为成熟性囊性畸胎瘤。然而，最终的组织病理学检查证实为源自MCT的鳞状细胞癌。该病例突出了冰冻切片分析在检测恶性肿瘤方面的局限性。
MCT恶变虽然罕见，但带来了重大的诊断和治疗挑战。全面的术前影像学检查和细致的术后组织病理学评估对于准确诊断和有效治疗至关重要。该病例强调了跨学科协作在处理复杂妇科病理情况中的重要性。
