Zhang K, Khan H, Seikaly H, Nichols A, Fung K, MacNeil S D, Mendez A
Schulich School of Medicine & Dentistry, Western University, London, Canada.
London Health Sciences Centre, London, Canada.
J Oral Pathol Med. 2025 Jul;54(6):455-458. doi: 10.1111/jop.13640. Epub 2025 May 2.
Patient-reported outcomes (PRO), which prioritize patient perspectives, are highly valuable for patient-centered care in Head and Neck Oncology. The objective of this study was to explore the longitudinal validity of the Edmonton-33 (E-33), a PRO instrument for assessing head and neck functions in swallowing, chewing, dry mouth, and speech.
This study involved 59 adult patients (18 female, 41 male) with squamous cell carcinoma (SCC) of the oral cavity. Participants provided consent and completed the E-33 and other PRO instruments before and after surgical and radiation treatment at months 3 (n = 18), 6 (n = 18), and 9 (n = 16). Data were collected (from June 2021 to August 2024) and analyzed for correlation between domains of the E-33 and their domain-specific, previously validated counterparts before treatment (baseline) and after treatment (Months 3, 6, and 9).
There were statistically significant correlations (p < 0.05) between all E-33 domains and their domain-specific counterparts at baseline and at post-treatment month 6. At Months 3 and 9 post-treatment, there were partial correlations between E-33 domains and some domain-specific counterparts.
The E-33 demonstrates validity pre-treatment and post-treatment at subacute timepoint (Months 6) for capturing data on swallowing, chewing, dry mouth, and speech, similar to other previously validated instruments. This validity is limited at the more acute timepoint of 3 months post-treatment and the later timepoint of 9 months post-treatment. Additional data are needed to further explore the long-term validity at further longitudinal timepoints at 1 and 2 years post-treatment.
患者报告结局（PRO）以患者视角为优先考量，对头颈肿瘤学中以患者为中心的护理极具价值。本研究的目的是探讨埃德蒙顿33项问卷（E-33）的纵向效度，这是一种用于评估吞咽、咀嚼、口干和言语方面头颈功能的PRO工具。
本研究纳入了59例成年口腔鳞状细胞癌（SCC）患者（18例女性，41例男性）。参与者在手术和放疗前及放疗后第3个月（n = 18）、第6个月（n = 18）和第9个月（n = 16）时提供了知情同意并完成了E-33及其他PRO工具。收集数据（从2021年6月至2024年8月），并分析E-33各领域与其在治疗前（基线）和治疗后（第3、6和9个月）特定领域的、先前已验证的对应指标之间的相关性。
在基线时以及治疗后第6个月，所有E-33领域与其特定领域的对应指标之间存在统计学显著相关性（p < 0.05）。在治疗后第3个月和第9个月，E-33领域与一些特定领域的对应指标之间存在部分相关性。
E-33在亚急性时间点（第6个月）治疗前和治疗后对于获取吞咽、咀嚼、口干和言语方面的数据显示出效度，类似于其他先前已验证的工具。这种效度在治疗后3个月这个更急性的时间点以及治疗后9个月这个较晚的时间点是有限的。需要更多数据以进一步探讨在治疗后1年和2年的进一步纵向时间点的长期效度。
