国际抗癫痫联盟神经影像学特别工作组重点关注：磁共振成像检测局灶性皮质发育异常所致的早期癫痫

ILAE neuroimaging task force highlight: MRI detection of early life epilepsy caused by focal cortical dysplasia.

作者信息

Cohen Nathan T, Vezina L Gilbert, Oluigbo Chima, Anwar Tayyba, Archer John, Bernhardt Boris C, Caciagli Lorenzo, Cendes Fernando, Chinvarun Yotin, Concha Luis, Federico Paolo, Kobayashi Eliane, Ogbole Godwin, Rampp Stefan, Vaudano Anna Elisabetta, Wang Z Irene, Wang Shuang, Winston Gavin P, Gaillard William D

机构信息

Center for Neuroscience Research, Children's National Hospital, the George Washington University School of Medicine, Washington, DC, USA.

Department of Neurology, Austin Health, the University of Melbourne, Parkville, Melbourne, Australia.

出版信息

Epileptic Disord. 2025 May 3. doi: 10.1002/epd2.70038.

DOI:10.1002/epd2.70038

PMID:40317795

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12353584/

Abstract

The ILAE Neuroimaging Task Force aims to publish educational case reports that highlight basic aspects of neuroimaging in epilepsy consistent with the ILAE's educational mission. Here, we describe a case series of three neonates with focal cortical dysplasia (FCD)-related drug-resistant epilepsy who underwent surgical intervention. The purpose of this series is to demonstrate the difficulties of identifying FCD in this age group and to highlight the potential added value of arterial spin labeling MRI for delineation of the epileptogenic zone. This series also supports the importance of the 2019 ILAE recommendations for structural imaging in epilepsy, the 2009 ILAE recommendations on imaging infants and children with recent-onset epilepsy, and the 2022 ILAE consensus classification of FCD.

摘要

国际抗癫痫联盟神经影像学特别工作组旨在发表教育性病例报告，突出癫痫神经影像学的基本方面，这与国际抗癫痫联盟的教育使命相一致。在此，我们描述了一组三名患有局灶性皮质发育不良（FCD）相关药物难治性癫痫的新生儿，他们接受了手术干预。本系列病例的目的是展示在这个年龄组中识别FCD的困难，并强调动脉自旋标记磁共振成像在描绘致痫区方面的潜在附加价值。本系列病例还支持2019年国际抗癫痫联盟关于癫痫结构成像的建议、2009年国际抗癫痫联盟关于对近期发作癫痫的婴儿和儿童进行成像的建议以及2022年国际抗癫痫联盟关于FCD的共识分类的重要性。