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耳廓狐(耳廓狐属)患惰性皮肤T细胞淋巴瘤的首例报告。

First report of indolent cutaneous T-cell lymphoma in a fennec fox (Vulpes zerda).

作者信息

Shekelle Kristen L, Glassman Alan R, Backues Kay A, Kilburn Jennifer J, Foust-Wheatcraft Desirae A, Stranahan Lauren Wood

机构信息

Department of Veterinary Pathobiology, TAMU, Texas A&M University, College of Veterinary Medicine, College Station, Texas, USA.

Tulsa Zoo, Tulsa, Oklahoma, USA.

出版信息

Vet Dermatol. 2025 Oct;36(5):707-711. doi: 10.1111/vde.13351. Epub 2025 May 2.

DOI:10.1111/vde.13351
PMID:40317829
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12420848/
Abstract

A 10-year-old fennec fox (Vulpes zerda) was presented for multifocal regions of chronic alopecia and crusting. Cutaneous lymphocytosis was diagnosed through histopathological examination and immunohistochemical investigation. Clonal rearrangement of the T-cell receptor gamma locus supports that lymphocytosis in this case was an indolent lymphoma.

摘要

一只10岁的耳廓狐(耳廓狐属)因多灶性慢性脱毛和结痂前来就诊。通过组织病理学检查和免疫组织化学研究诊断为皮肤淋巴细胞增多症。T细胞受体γ基因座的克隆重排支持该病例中的淋巴细胞增多症为惰性淋巴瘤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b815/12420848/bf291e3385b2/VDE-36-707-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b815/12420848/b7a7a690a44a/VDE-36-707-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b815/12420848/649bd7fadcdb/VDE-36-707-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b815/12420848/97a6d45a3018/VDE-36-707-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b815/12420848/bf291e3385b2/VDE-36-707-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b815/12420848/b7a7a690a44a/VDE-36-707-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b815/12420848/649bd7fadcdb/VDE-36-707-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b815/12420848/97a6d45a3018/VDE-36-707-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b815/12420848/bf291e3385b2/VDE-36-707-g005.jpg

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本文引用的文献

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A 40-YEAR (1980-2019) RETROSPECTIVE REVIEW OF MORBIDITY AND MORTALITY OF FENNEC FOXES () AT THE BRONX AND PROSPECT PARK ZOOS.一项关于布朗克斯动物园和展望公园动物园的雪狐()发病率和死亡率的 40 年(1980-2019 年)回顾性研究。
J Zoo Wildl Med. 2023 Jul;54(2):252-261. doi: 10.1638/2022-0167.
2
A clonality analysis based on T-cell receptor beta and delta loci for high-grade gastrointestinal lymphoma in dogs.基于 T 细胞受体β和δ基因座的克隆性分析用于诊断犬的高级胃肠道淋巴瘤。
J Vet Diagn Invest. 2022 Nov;34(6):972-976. doi: 10.1177/10406387221116285. Epub 2022 Aug 2.
3
Feline and Canine Cutaneous Lymphocytosis: Reactive Process or Indolent Neoplastic Disease?
猫和犬皮肤淋巴细胞增多症:反应性过程还是惰性肿瘤性疾病?
Vet Sci. 2022 Jan 11;9(1):26. doi: 10.3390/vetsci9010026.
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Novel clonality assays for T cell lymphoma in cats targeting the T cell receptor beta, T cell receptor delta, and T cell receptor gamma loci.针对 T 细胞受体 β、T 细胞受体 δ 和 T 细胞受体 γ 基因座的新型 T 细胞淋巴瘤猫克隆性检测方法。
J Vet Intern Med. 2021 Nov;35(6):2865-2875. doi: 10.1111/jvim.16288. Epub 2021 Dec 20.
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A novel clonality assay for the assessment of canine T cell proliferations.一种用于评估犬T细胞增殖的新型克隆性检测方法。
Vet Immunol Immunopathol. 2012 Jan 15;145(1-2):410-9. doi: 10.1016/j.vetimm.2011.12.019. Epub 2011 Dec 28.
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Multiplex PCR and Genescan analysis to detect immunoglobulin heavy chain gene rearrangement in feline B-cell neoplasms.多重聚合酶链反应和基因扫描分析检测猫B细胞肿瘤中的免疫球蛋白重链基因重排。
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