Wang Dan, Shi Hanzhu, Ma Liangjun, Zhou Xue, Zhang Rongrong, Xu Yanhong, Li Lu, Zhang Lingyu, Wang Chungang
Key Laboratory of Preparation and Applications of Environmentally Friendly Materials, Key Laboratory of Functional Materials Physics and Chemistry of the Ministry of Education (Jilin Normal University), Ministry of Education, Changchun 130103, China; Department of Chemistry, Northeast Normal University, Changchun 130024, China.
Anhui Academy of Medical Sciences, Anhui Medical College, Hefei 230061, China.
J Colloid Interface Sci. 2025 Sep 15;694:137696. doi: 10.1016/j.jcis.2025.137696. Epub 2025 Apr 24.
The development of novel nanozymes with excellent enzyme simulation ability provides a new perspective for antibacterial and wound healing. However, the enzyme activity of traditional simplex nanozyme is not sufficient, meanwhile the nanozymic catalytic therapy alone cannot fulfill the purpose of effective antibacterial and wound healing. Hence, we develop novel multifunctional nanocomposites composed of FeCo alloys integrate with carbon spheres and carbon nanotubes (FeCo-C/CNT NCs) with hydrophobic property, enhanced oxidase-like (OXD-like) activity and photothermal property. Remarkably, in vitro experiment shows the antibacterial rates of 200 μg/mL FeCo-C/CNT NCs against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) are as high as 83.46 % and 90.98 %, respectively. The mechanism of synergistic antibacterial effect is not only due to the reactive oxygen species (ROS) generation from FeCo alloy part of FeCo-C/CNT NCs, but also because the local high temperature generated by the photothermal effects of FeCo-C/CNT NCs under near infrared (NIR) laser irradiation, as well as heat promoted ROS production. The FeCo-C/CNT NCs under NIR laser irradiation present best wound healing via hydrophobic protection, synergistic catalytic and photothermal therapy on S. aureus-infected mice. This work introduces a novel alloy nanozyme with excellent antibacterial property, providing new idea in the field of wound healing.
具有优异酶模拟能力的新型纳米酶的开发为抗菌和伤口愈合提供了新的视角。然而，传统单一纳米酶的酶活性不足，同时仅靠纳米酶催化疗法无法实现有效的抗菌和伤口愈合目的。因此，我们开发了由铁钴合金与碳球和碳纳米管（FeCo-C/CNT NCs）组成的新型多功能纳米复合材料，其具有疏水性、增强的类氧化酶（OXD-like）活性和光热性能。值得注意的是，体外实验表明，200μg/mL的FeCo-C/CNT NCs对金黄色葡萄球菌（S. aureus）和大肠杆菌（E. coli）的抗菌率分别高达83.46%和90.98%。协同抗菌作用的机制不仅是由于FeCo-C/CNT NCs的铁钴合金部分产生活性氧（ROS），还因为在近红外（NIR）激光照射下FeCo-C/CNT NCs的光热效应产生的局部高温以及热促进ROS的产生。在NIR激光照射下，FeCo-C/CNT NCs通过对感染金黄色葡萄球菌的小鼠进行疏水保护、协同催化和光热疗法，呈现出最佳的伤口愈合效果。这项工作引入了一种具有优异抗菌性能的新型合金纳米酶，为伤口愈合领域提供了新思路。
