Cetera B, Bugajski J, Gadek-Michalska A
Institute of Pharmacology, Polish Academy of Sciences, Kraków.
Agents Actions. 1988 Apr;23(3-4):250-3. doi: 10.1007/BF02142555.
The effect of intracerebroventricular (i.c.v.) administration of morphine on corticosterone secretion was studied in conscious, unstressed rats. A dose-dependent increase in serum corticosterone levels was observed 1 h after morphine injection. The corticosterone response to morphine was antagonized in a dose-dependent manner, and at larger dose almost abolished, by i.c.v. pretreatment of rats with naloxone, an opioid receptor antagonist. Intraventricular pretreatment of rats with mepyramine and cimetidine, the histamine H1- and H2-receptor antagonists, significantly diminished the corticosterone response to morphine. These results suggest that central opioid receptors are involved in the stimulating effect of morphine on the hypothalamo-pituitary-adrenocortical axis. Central histamine H1- and H2-receptors seem to be substantially involved in the stimulatory effect of morphine on corticosterone secretion in conscious, unstressed rats.
在清醒、未受应激的大鼠中研究了脑室内注射吗啡对皮质酮分泌的影响。吗啡注射1小时后观察到血清皮质酮水平呈剂量依赖性升高。用阿片受体拮抗剂纳洛酮对大鼠进行脑室内预处理，可剂量依赖性地拮抗皮质酮对吗啡的反应，且在较大剂量时几乎完全消除该反应。用组胺H1和H2受体拮抗剂美吡拉敏和西咪替丁对大鼠进行脑室内预处理，可显著减弱皮质酮对吗啡的反应。这些结果表明，中枢阿片受体参与了吗啡对下丘脑-垂体-肾上腺皮质轴的刺激作用。中枢组胺H1和H2受体似乎在很大程度上参与了吗啡对清醒、未受应激大鼠皮质酮分泌的刺激作用。
