从成年猪脑分离的少突胶质细胞的甘油磷酸脱氢酶活性：其受氢化可的松的诱导性。

Glycerol phosphate dehydrogenase activity of oligodendrocytes isolated from adult pig brain: its inducibility by hydrocortisone.

作者信息

Montz H P, Althaus H H, Gebicke-Haerter P J, Neuhoff V

出版信息

J Neurochem. 1985 Oct;45(4):1201-4. doi: 10.1111/j.1471-4159.1985.tb05542.x.

DOI:10.1111/j.1471-4159.1985.tb05542.x

Abstract

Developing oligodendrocytes cultured in vitro express glycerol phosphate dehydrogenase (GPDH; EC 1.1.1.8) and are known to respond to glucocorticoid treatment by increased activity of GPDH. We present evidence that GPDH is enriched in white matter and oligodendrocytes of adult pig brain. Bulk-isolated oligodendrocytes maintained in culture for several weeks exhibit an almost constant level of GPDH activity. Furthermore, a 4-day stimulation with hydrocortisone induces GPDH specific activity of long-term cultured oligodendrocytes from adult pig brain.

摘要

体外培养的发育中的少突胶质细胞表达甘油磷酸脱氢酶（GPDH；EC 1.1.1.8），并且已知其对糖皮质激素治疗的反应是GPDH活性增加。我们提供的证据表明，GPDH在成年猪脑的白质和少突胶质细胞中含量丰富。批量分离并在培养中维持数周的少突胶质细胞表现出几乎恒定水平的GPDH活性。此外，用氢化可的松进行4天的刺激可诱导成年猪脑长期培养的少突胶质细胞的GPDH比活性。

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