Romijnders Kim A G J, Romero Gonzalez Franco, Matser Amy, Verburgh Myrthe L, Dijkstra Maartje, Reiss Peter, Kretzschmar Mirjam, Nieuwkerk Pythia, Schim van der Loeff Maarten, Basten Maartje, Rozhnova Ganna
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Department of Infectious Diseases, Public Health Service of Amsterdam, Amsterdam, The Netherlands.
Commun Med (Lond). 2025 May 3;5(1):152. doi: 10.1038/s43856-025-00853-3.
This study explored the expected impact of two hypothetical HIV cure scenarios on quality of life, sexual satisfaction, and stigma among people with HIV and key populations (i.e., partners and communities of people with HIV and men who have sex with men without HIV) in the Netherlands.
A cross-sectional survey was conducted among people with HIV and key populations from October 2021 until June 2022. We assessed quality of life, sexual satisfaction, and stigma using linear regression and mixed models to compare participants' current situation with two hypothetical HIV cure scenarios: HIV post-intervention control, where HIV is suppressed without the need for ongoing antiretroviral treatment, but the viral reservoir is expected to persist, and HIV elimination, where HIV is completely removed from the body.
Our findings show that people with HIV (n = 222) expect improved quality of life and sexual satisfaction, as well as reduced stigma, compared to their current situation following both post-intervention control and elimination. Key populations (n = 495) similarly expect improvements for both HIV cure scenarios, except no expected improvement was found for quality of life following post-intervention control. Participants aged 18 to 34 anticipate greater improvements from both cure scenarios than those over 34.
Both people with HIV and key populations without HIV expect an HIV cure to have a positive impact on quality of life, sexual satisfaction, and stigma. This impact is expected not only for HIV elimination but also for HIV post-intervention control, the development of which appears more feasible.
本研究探讨了两种假设的艾滋病治愈方案对荷兰艾滋病患者及关键人群（即艾滋病患者的伴侣和社区以及未感染艾滋病的男男性行为者）的生活质量、性满意度和耻辱感的预期影响。
2021年10月至2022年6月，对艾滋病患者及关键人群进行了横断面调查。我们使用线性回归和混合模型评估生活质量、性满意度和耻辱感，以将参与者的现状与两种假设的艾滋病治愈方案进行比较：干预后艾滋病控制，即无需持续抗逆转录病毒治疗即可抑制艾滋病病毒，但预计病毒储存库将持续存在；以及艾滋病消除，即从体内完全清除艾滋病病毒。
我们的研究结果表明，与干预后控制和消除后的现状相比，艾滋病患者（n = 222）预期生活质量和性满意度会提高，耻辱感会降低。关键人群（n = 495）对两种艾滋病治愈方案也同样预期会有所改善，但干预后控制后的生活质量未发现预期改善。18至34岁的参与者预计两种治愈方案带来的改善都比34岁以上的参与者更大。
艾滋病患者和未感染艾滋病的关键人群都预期艾滋病治愈会对生活质量、性满意度和耻辱感产生积极影响。这种影响不仅预期在艾滋病消除方面，而且在干预后艾滋病控制方面也会出现，干预后控制的发展似乎更可行。
