Adams C W, Poston R N, Buk S J, Sidhu Y S, Vipond H
J Neurol Sci. 1985 Jul;69(3):269-83. doi: 10.1016/0022-510x(85)90139-x.
Fifty-two plaque or lesion areas were examined from 25 cases of multiple sclerosis. Twenty-four of these showed acute features, whereas the rest were more chronic in nature. The acute lesions showed lymphocytic infiltration (79%), fibrinous exudation (63%), lymphocytic meningitis (50%) and venulitis (58%). Of the chronic lesions, there were only 21% with lymphocytic infiltration, 11% with fibrinous exudates, none with meningitis, 29% with organising endovenulitis, 36% with fibrosed vein walls. The finding of a fibrinous inflammatory exudate in the acute lesion is a new observation in multiple sclerosis. Likewise, the observation of an inflammatory infiltrate confined to the vein wall (and often present at a distance from the plaque) has not been previously recorded in the disease. The chronic lesion, by contrast, showed relatively little fibrin, but there was considerable reparative thickening of the walls of the involved veins. The evidence provides new humoral and cellular evidence of an inflammatory process in multiple sclerosis which precedes or is not directly associated with the demyelinating process.
对25例多发性硬化症患者的52个斑块或病变区域进行了检查。其中24个表现为急性特征，其余的则更具慢性特征。急性病变表现为淋巴细胞浸润（79%）、纤维蛋白渗出（63%）、淋巴细胞性脑膜炎（50%）和静脉炎（58%）。在慢性病变中，仅有21%存在淋巴细胞浸润，11%有纤维蛋白渗出，无脑膜炎病例，29%有组织化的静脉内膜炎，36%有静脉壁纤维化。在急性病变中发现纤维蛋白性炎性渗出物是多发性硬化症中的一项新观察结果。同样，局限于静脉壁（且常出现在距斑块一定距离处）的炎性浸润这一观察结果在该疾病中此前尚未有记录。相比之下，慢性病变显示纤维蛋白相对较少，但受累静脉壁有相当程度的修复性增厚。该证据为多发性硬化症中在脱髓鞘过程之前或与之无直接关联的炎性过程提供了新的体液和细胞证据。
