Tidei Joseph J, Oakes Patrick W, Beach Jordan R
Dept. Cell & Molecular Physiology, Loyola University Chicago, Stritch School of Medicine, Maywood, IL 60153, USA.
Dept. Cell & Molecular Physiology, Loyola University Chicago, Stritch School of Medicine, Maywood, IL 60153, USA.
Curr Opin Cell Biol. 2025 Jun;94:102522. doi: 10.1016/j.ceb.2025.102522. Epub 2025 May 3.
Cells derive their shape, and in turn much of their behavior, from the organization of the cytoskeleton. While a myriad of proteins contribute to the regulation and organization of this dynamic structure, two of the principal components are actin filaments, which provide the structure, and myosin motors, which generate the majority of the forces. Here we review recent results on the assembly and kinetics of non-muscle myosin 2, and highlight how the cellular environment modulates local myosin behavior and signaling.
细胞的形状以及许多行为都源自细胞骨架的组织架构。虽然众多蛋白质参与了这一动态结构的调节和组织，但其中两个主要成分是肌动蛋白丝（提供结构）和肌球蛋白马达（产生大部分力）。在这里，我们回顾了关于非肌肉肌球蛋白2组装和动力学的最新研究成果，并强调细胞环境如何调节局部肌球蛋白的行为和信号传导。
