Abbasi Ebrahim
Research Center for Health Sciences, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Medical Entomology and Vector Control, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran.
Epidemiol Rev. 2025 Jan 10;47(1). doi: 10.1093/epirev/mxaf006.
Dengue fever, caused by the dengue virus (DENV) and transmitted by Aedes aegypti mosquitos, remains a global health concern with no definitive treatment. Given the challenges in vaccine development and disease management, micronutrients such as vitamin D have emerged as potential adjunctive therapies because of their immunomodulatory properties. The effectiveness of vitamin D in the prevention and control of dengue fever was assessed in this systematic review by evaluating vitamin D's impact on immune responses, viral replication, and clinical outcomes. Following Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines, relevant studies were retrieved from the PubMed, Web of Science, and Scopus databases. Inclusion criteria encompassed studies examining the association between vitamin D and DENV infection, disease severity, and immune modulation. Six studies met the inclusion criteria. Findings indicated that vitamin D supplementation reduced pro-inflammatory cytokine levels, enhanced macrophage responses, and modulated toll-like receptor activity. Higher vitamin D levels were associated with lower viral replication and milder clinical manifestations of dengue fever. Vitamin D demonstrates potential as an adjunctive therapy for dengue fever by modulating immune responses and reducing disease severity. More clinical trials are required to validate its therapeutic efficacy and determine optimal supplementation strategies. Trial registration: International Prospective Register of Systematic Review identifier: CRD42021231605.
登革热由登革病毒（DENV）引起，通过埃及伊蚊传播，仍然是一个全球关注的健康问题，且尚无确切的治疗方法。鉴于疫苗开发和疾病管理方面的挑战，维生素D等微量营养素因其免疫调节特性已成为潜在的辅助治疗方法。本系统评价通过评估维生素D对免疫反应、病毒复制和临床结局的影响，来评估维生素D在预防和控制登革热方面的有效性。按照系统评价和Meta分析的首选报告项目指南，从PubMed、科学网和Scopus数据库中检索相关研究。纳入标准包括研究维生素D与DENV感染、疾病严重程度和免疫调节之间的关联。六项研究符合纳入标准。研究结果表明，补充维生素D可降低促炎细胞因子水平，增强巨噬细胞反应，并调节Toll样受体活性。较高的维生素D水平与较低的病毒复制及登革热较轻的临床表现相关。维生素D通过调节免疫反应和降低疾病严重程度，显示出作为登革热辅助治疗方法的潜力。需要更多的临床试验来验证其治疗效果并确定最佳补充策略。试验注册：国际系统评价前瞻性注册库标识符：CRD42021231605。
