Abbasi Ebrahim
Research Center for Health Sciences, Institute of Health, https://ror.org/01n3s4692Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Medical Entomology and Vector Control, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran.
Epidemiol Infect. 2025 Aug 1;153:e88. doi: 10.1017/S0950268825100320.
Dengue virus (DENV) remains a pressing global health challenge, primarily transmitted by mosquitoes. This review synthesizes current knowledge on the biological, environmental, and molecular factors influencing DENV transmission, drawing upon 120 peer-reviewed studies. The narrative analysis highlights the mosquito’s vector competence, shaped by genetic variability, midgut barriers, and immune responses. Environmental drivers particularly temperature, humidity, and urbanization emerge as critical determinants of transmission dynamics. A meta-analysis of 30 studies reveals a strong positive correlation ( = 0.85, < 0.01) between temperature (25 °C–30 °C) and transmission efficiency. Proteomic studies further detail molecular interactions facilitating viral entry and replication. Although novel interventions such as Wolbachia-based biocontrol and genetic modification show promise, context-specific implementation remains challenging, especially in low-resource settings. Key research gaps include the impact of climate change, co-infections with other arboviruses, and the long-term efficacy of vector control innovations. Prioritizing interdisciplinary approaches and adapting strategies to local contexts are vital to reducing the dengue burden and informing future public health responses.
登革病毒（DENV）仍然是一个紧迫的全球健康挑战，主要通过蚊子传播。本综述综合了120篇同行评议研究中关于影响登革病毒传播的生物学、环境和分子因素的现有知识。叙述性分析强调了蚊子的媒介能力，其受到遗传变异性、中肠屏障和免疫反应的影响。环境驱动因素，特别是温度、湿度和城市化，成为传播动态的关键决定因素。对30项研究的荟萃分析显示，温度（25°C至30°C）与传播效率之间存在强烈的正相关（r = 0.85，p < 0.01）。蛋白质组学研究进一步详细阐述了促进病毒进入和复制的分子相互作用。尽管基于沃尔巴克氏体的生物防治和基因改造等新干预措施显示出前景，但因地制宜的实施仍然具有挑战性，尤其是在资源匮乏的地区。关键的研究差距包括气候变化的影响、与其他虫媒病毒的共同感染以及病媒控制创新的长期效果。优先考虑跨学科方法并使策略适应当地情况对于减轻登革热负担和为未来的公共卫生应对提供信息至关重要。
