Zemcov A, Barclay L L, Sansone J, Metz C E
J Nucl Med. 1985 Sep;26(9):1002-10.
Receiver operating characteristic (ROC) curves were used to quantitatively assess the ability of individual detectors in a 32-detector 133Xe inhalation system to discriminate between two populations over the range of regional cerebral blood flow (rCBF) values. These populations were clinically evaluated as normal (age 63.1 +/- 13.1, n = 23) and presumed Alzheimer's disease (age 72.7 +/- 7.0, n = 82). Summary statistics showed that for homologous detectors the average value of blood flow in the normal group was greater than the flow value in the group of subjects with Alzheimer's disease. Conclusions drawn from single values of flow or mean hemispheric flow can lead to erroneous conclusions about hemisphere asymmetries. However, the dynamic relationship between the correct identifications (true positives) compared with incorrect identifications (false positives) of Alzheimer's disease at each detector varies over the range of blood flow values, and quantitative characterization of this relationship in terms of an ROC curve provides more insight into the structure of the data. Detectors approximating the speech, auditory and association cortex were most effective in discriminating between groups. Frontal detectors were marginally useful diagnostically.
受试者工作特征（ROC）曲线用于定量评估32探测器133Xe吸入系统中各个探测器在区域脑血流（rCBF）值范围内区分两个人群的能力。这两个人群在临床上被评估为正常人群（年龄63.1±13.1，n = 23）和疑似阿尔茨海默病患者（年龄72.7±7.0，n = 82）。汇总统计数据表明，对于同源探测器，正常组的血流平均值大于阿尔茨海默病患者组的血流值。从单个血流值或平均半球血流得出的结论可能会导致关于半球不对称性的错误结论。然而，在每个探测器上，阿尔茨海默病的正确识别（真阳性）与错误识别（假阳性）之间的动态关系在血流值范围内有所不同，并且根据ROC曲线对这种关系进行定量表征可以更深入地了解数据结构。接近言语、听觉和联合皮质的探测器在区分两组时最有效。额叶探测器在诊断上的作用不大。
