Pierson R N, Yamashina A, Friedman M I, Roistacher N
J Nucl Med. 1985 Sep;26(9):994-1001.
Previous reports have suggested that left ventricular first-third ejection fraction (EF) can be obtained from the left ventricular time-activity curve derived from first-pass radionuclide angiography based on Anger camera data. The validity of this technique was assessed by: a study of beat-to-beat variations in data from 15 patients in which electrocardiographic data were simultaneously recorded, and a computer simulation incorporating the application of Poisson statistics to appropriate count rate data. The results of patients studies showed no consistent trend in any first-third parameter obtained from consecutive beats in individual subjects, and unacceptably high statistical uncertainty in the calculation of the first-third ejection fraction. The weighted standard deviation of the first-third ejection fraction in each of 15 patients studied averaged 7.5 EF units, while first-third ejection fraction averaged 22.9 EF units. The relative error averaged 32%. The computer simulation indicated a high relative error of 47% associated with the first-third ejection fraction at typical end-diastolic count rates of 200 per frame from 1,000 computer Poisson randomizations of an appropriate analog volume curve. The results render the first-pass radiocardiographic method invalid for determining first-third ejection fraction.
先前的报告表明，基于安杰尔相机数据的首次通过放射性核素血管造影所得到的左心室时间-活度曲线，可用于获取左心室前三分之一射血分数（EF）。通过以下方式评估了该技术的有效性：对15例患者的数据进行逐搏变化研究，同时记录心电图数据；以及进行计算机模拟，将泊松统计应用于适当的计数率数据。患者研究结果显示，在个体受试者连续心搏获得的任何前三分之一参数中均无一致趋势，且在计算前三分之一射血分数时存在高得无法接受的统计不确定性。在研究的15例患者中，每例患者的前三分之一射血分数加权标准差平均为7.5个EF单位，而前三分之一射血分数平均为22.9个EF单位。相对误差平均为32%。计算机模拟表明，对合适的模拟容积曲线进行1000次计算机泊松随机化后，在每帧200的典型舒张末期计数率下，与前三分之一射血分数相关的相对误差高达47%。这些结果表明，首次通过放射性心动图方法无法有效测定前三分之一射血分数。
