Nichols K, DePuey E G, Gooneratne N, Salensky H, Friedman M, Cochoff S
Department of Radiology, St. Luke's-Roosevelt Hospital Center, New York, NY 10025.
J Nucl Med. 1994 Aug;35(8):1292-300.
The purpose of the study was to evaluate the reliability of ejection fractions obtained from first-pass radionuclide ventriculography with a large field-of-view tomographic single-crystal gamma camera.
A SPECT camera had its electronics redesigned to improve counting efficiency and was equipped with an experimental ultra-high sensitivity collimator. Left ventricular ejection fraction (LVEF) was measured in 28 patients by 30 degrees RAO first-pass imaging and by "best septal view" LAO planar equilibrium radionuclide ventriculography on a conventional small field of view Anger camera. For 28 other patients, first-pass ejection fractions were compared to multicrystal gamma camera values. Visual analysis was performed to judge clinical acceptability of first-pass images for identification of wall-motion abnormalities.
Linear regression analysis of first-pass against equilibrium ejection fraction demonstrated good correlation (r = 0.92; slope = 0.90; intercept = 3.8; s.e.e. = 6.4%). First-pass ejection fraction values also correlated linearly with multicrystal camera values for the left ventricle (r = 0.94; slope = 1.05; intercept = 1.3; s.e.e. = 5.3%). For a subgroup of 19 patients, single-crystal camera right ventricle ejection fraction demonstrated good correlation with multicrystal camera values (r = 0.82; slope = 1.15; intercept = 1.3; s.e.e. = 6.1%). Interobserver variability correlated as r = 0.99 for LVEF ejection fraction and r = 0.92 for RVEF. Chi-square analysis of single-crystal first-pass image visual scores versus those from the gated equilibrium acquisitions showed close agreement (p < 10(-8)).
The evaluated camera/collimator system measured left and right ventricular ejection fraction accurately. Lung frame correction and dual regions were superior to paraventricular background correction and a fixed end-diastolic region.
本研究的目的是评估使用大视野断层单晶伽马相机通过首次通过放射性核素心室造影获得的射血分数的可靠性。
一台单光子发射计算机断层显像（SPECT）相机对其电子设备进行了重新设计以提高计数效率，并配备了实验性超高灵敏度准直器。通过30度右前斜位首次通过成像以及在传统小视野安杰尔相机上通过“最佳间隔视图”左前斜位平面平衡放射性核素心室造影对28例患者测量左心室射血分数（LVEF）。对于另外28例患者，将首次通过射血分数与多晶体伽马相机测量值进行比较。进行视觉分析以判断首次通过图像对识别室壁运动异常的临床可接受性。
首次通过射血分数与平衡射血分数的线性回归分析显示出良好的相关性（r = 0.92；斜率 = 0.90；截距 = 3.8；标准误差 = 6.4%）。首次通过射血分数值与左心室多晶体相机测量值也呈线性相关（r = 0.94；斜率 = 1.05；截距 = 1.3；标准误差 = 5.3%）。对于19例患者的亚组，单晶相机右心室射血分数与多晶体相机测量值显示出良好的相关性（r = 0.82；斜率 = 1.15；截距 = 1.3；标准误差 = 6.1%）。观察者间变异性对于LVEF射血分数的相关性为r = 0.99，对于RVEF的相关性为r = 0.92。单晶首次通过图像视觉评分与门控平衡采集图像视觉评分的卡方分析显示出密切一致性（p < 10⁻⁸）。
所评估的相机/准直器系统能够准确测量左、右心室射血分数。肺野校正和双区域校正优于心室旁背景校正和固定的舒张末期区域。
