Toda T, Mahfouz M M, Kummerow F A
Acta Pathol Jpn. 1984 Sep;34(5):935-45.
The effects of trans-fatty acid-rich and saturated acid-rich diets on the fatty acid composition and morphology of swine arterial tissues were studied. Three groups of two-month-old swine were fed either a basal diet or a basal diet containing 8.3% margarine or butter for 4 months. The most significant change observed in the fatty acid pattern was the accumulation of 18 : 2 omega 6 and the suppression of both 20 : 4 omega 6 and 22 : 4 omega 6 acids in the aortic tissues of swine fed either butter or margarine as compared to swine fed the basal diet. Also, omega 6 metabolites were significantly decreased in swine fed diets containing butter or margarine, as compared to those fed a basal diet. The group of swine which were fed either butter or margarine containing diets suffered a significant increase in intimal thickening of the coronary artery compared to those fed the basal diet. These thickened intima were characterized by the presence of modified smooth muscle cells, lipid containing cells, and degenerated cells without stainable lipids. However, there was no significant difference in the incidence and extent of intimal thickening of the coronary arteries between swine fed either of the two fat containing diets.
研究了富含反式脂肪酸和饱和脂肪酸的饮食对猪动脉组织脂肪酸组成和形态的影响。将三组两个月大的猪分别喂食基础日粮，或含有8.3%人造黄油或黄油的基础日粮，持续4个月。与喂食基础日粮的猪相比，在喂食黄油或人造黄油的猪的主动脉组织中，观察到的脂肪酸模式最显著变化是18:2ω6的积累以及20:4ω6和22:4ω6酸的减少。此外，与喂食基础日粮的猪相比，喂食含黄油或人造黄油日粮的猪体内ω6代谢物显著减少。与喂食基础日粮的猪相比，喂食含黄油或人造黄油日粮的猪冠状动脉内膜增厚显著增加。这些增厚的内膜特征是存在形态改变的平滑肌细胞、含脂细胞和无脂质可染的退化细胞。然而，喂食两种含脂肪日粮的猪之间，冠状动脉内膜增厚的发生率和程度没有显著差异。
