Department of Ophthalmology, Chonnam National University Medical School and Hospital, Gwangju, South Korea.
Department of Neurology, Chonnam National University Medical School and Hospital, Gwangju, South Korea.
Sci Rep. 2019 Aug 14;9(1):11832. doi: 10.1038/s41598-019-48388-7.
We investigated the association between retinal changes measured using optical coherence tomography (OCT) and diverse clinical grading scales in patients with Parkinson's disease (PD). Seventy-four eyes of 74 patients with de novo PD and 53 eyes of age-matched control subjects were included. The thickness of the peripapillary retinal nerve fiber layer (pRNFL) and macular ganglion cell-inner plexiform layer (mGCIPL) were measured. We analyzed the correlations between the clinical PD grading scales and OCT parameters, and between the OCT parameters and volumetric data in the cerebral cortical and subcortical structures. The area under the receiver operating characteristic curve (AUC) was calculated for diagnosing cognitive impairment in patients with PD. Statistically significant reductions in the thickness of average, temporal, and inferior pRNFL and overall mGCIPL were observed in patients with PD. The Montreal Cognitive Assessment score was significantly associated with mGCIPL thinning. The AUC of the mGCIPL parameters for diagnosing cognitive impairment in patients with PD ranged from 0.651 to 0.760. Moreover, thinning of the mGCIPL was significantly associated with the volumetric parameters of associated brain structures. Our findings highlight the clinical implications of OCT measurements as a potential biomarker for early detection of cognitive impairment in patients with PD.
我们研究了使用光学相干断层扫描（OCT）测量的视网膜变化与帕金森病（PD）患者多种临床分级量表之间的关系。纳入了 74 例初诊 PD 患者的 74 只眼和 53 只年龄匹配的对照者的眼。测量了视盘周围视网膜神经纤维层（pRNFL）和黄斑神经节细胞-内丛状层（mGCIPL）的厚度。我们分析了临床 PD 分级量表与 OCT 参数之间、OCT 参数与大脑皮质和皮质下结构容积数据之间的相关性。计算了 OCT 诊断 PD 患者认知障碍的受试者工作特征曲线（ROC）下面积（AUC）。PD 患者的平均、颞侧和下侧 pRNFL 以及整体 mGCIPL 厚度明显降低。蒙特利尔认知评估评分与 mGCIPL 变薄显著相关。mGCIPL 参数诊断 PD 患者认知障碍的 AUC 范围为 0.651 至 0.760。此外，mGCIPL 变薄与相关脑结构的容积参数显著相关。我们的研究结果强调了 OCT 测量作为早期检测 PD 患者认知障碍的潜在生物标志物的临床意义。
