Soleimani Sadaf, Talesh Sasani Soheila, Salehi Zivar, Fakour Fereshteh
Department of Biology, Faculty of Sciences, University of Guilan, Rasht, Iran.
Medicine School, Guilan Medical University, Rasht, Iran.
Mol Biol Res Commun. 2025;14(3):199-202. doi: 10.22099/mbrc.2025.51763.2065.
Breast cancer (BC) is the main cause of cancer-related death in women worldwide. We evaluated the association between the key gene variant; rs9344 (G>A); and BC risk in Iran. In this case-control study, blood samples were obtained from 58 patients and 66 healthy controls. Genotyping was conducted by tetra-primer amplification refractory mutation system PCR (T-ARMS-PCR). Statistical analysis was performed by MedCalc software. Our results showed that the polymorphism rs9344 has an association with BC risk in the Iranian population. Based on the codominant and recessive models, carriers of the AA genotype are nearly 3.5 times more susceptible to BC than other individuals, and the AA genotype of A870G may be a significant factor for breast cancer. Further studies are needed to clarify the roles of polymorphism, rs9344, in breast cancer.
乳腺癌（BC）是全球女性癌症相关死亡的主要原因。我们评估了关键基因变异rs9344（G>A）与伊朗人群患BC风险之间的关联。在这项病例对照研究中，采集了58例患者和66例健康对照者的血样。采用四引物扩增阻滞突变系统PCR（T-ARMS-PCR）进行基因分型。使用MedCalc软件进行统计分析。我们的结果表明，多态性rs9344与伊朗人群患BC的风险相关。基于共显性和隐性模型，AA基因型携带者患BC的易感性比其他个体高近3.5倍，A870G的AA基因型可能是乳腺癌的一个重要因素。需要进一步研究来阐明多态性rs9344在乳腺癌中的作用。
