Player Jacob K, Msibi Sithembiso S, Bouzigard Rory, Arnold Mark, Mang Norman, Hall Brenton, Su L Joseph, Lane Michael A, Perl Trish M, Castellino Laila M
University of Texas Southwestern Medical School, Dallas, Texas, USA.
Peter O'Donnell Jr School of Public Health, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Open Forum Infect Dis. 2025 Apr 28;12(5):ofaf244. doi: 10.1093/ofid/ofaf244. eCollection 2025 May.
Outpatient parenteral antimicrobial therapy (OPAT) decreases length of stay and inpatient costs while benefiting patients. However, costs in the ambulatory setting are poorly quantified. To address this gap, we examined both inpatient costs avoided and uncompensated labor associated with OPAT delivered via 3 administration models: self-administration (S-OPAT), home care agencies/hemodialysis centers (HH-OPAT), and skilled nursing facilities (SNF-OPAT).
The length and type of treatment and postdischarge nonbillable encounters were reviewed via the electronic health record for all adult patients admitted to a large urban hospital and discharged on OPAT during two 3-month periods. Average daily inpatient care costs for Texas state hospitals and antibiotic wholesale acquisition costs were used to estimate OPAT costs and savings. Antibiotics with different formulations were converted to equivalent daily doses and their corresponding costs were averaged to estimate a daily cost.
Among 342 patient records examined during the study periods, which accounted for 8656 inpatient days avoided, there were 211.1 nonbillable encounters per 100 patient-days of OPAT for patients discharged in SNF-OPAT, 9.1 in HH-OPAT, and 6.4 in S-OPAT ( = .028). The estimated cost avoided per 100 patient-days was $376 400 or approximately $5 430 197 per month.
A substantial burden of uncompensated labor was associated with all OPAT modalities; however, coordinating care with skilled nursing facilities was significantly more demanding when adjusted for days of OPAT. All OPAT models generated significant institutional savings, which are typically overestimated as they fail to account for the uncompensated support provided by the ambulatory care staff.
门诊胃肠外抗菌治疗(OPAT)可缩短住院时间并降低住院费用,同时使患者受益。然而,门诊环境中的费用却难以量化。为填补这一空白,我们研究了通过三种给药模式(自我给药(S-OPAT)、家庭护理机构/血液透析中心(HH-OPAT)和专业护理机构(SNF-OPAT))进行OPAT所避免的住院费用以及未得到补偿的劳动力情况。
通过电子健康记录回顾了在两个为期3个月的时间段内入住一家大型城市医院并接受OPAT出院的所有成年患者的治疗时长和类型以及出院后的非计费诊疗情况。使用德克萨斯州医院的平均每日住院护理费用和抗生素批发采购成本来估算OPAT成本和节省的费用。将不同剂型的抗生素换算为等效日剂量,并对其相应成本进行平均以估算每日成本。
在研究期间检查的342份患者记录中,共避免了8656个住院日,接受SNF-OPAT出院的患者每100个OPAT患者日有211.1次非计费诊疗,HH-OPAT为9.1次,S-OPAT为6.4次(P = 0.028)。每100个患者日估计避免的成本为376400美元,即每月约5430197美元。
所有OPAT模式均存在大量未得到补偿的劳动力负担;然而,在按OPAT天数进行调整后,与专业护理机构协调护理的要求明显更高。所有OPAT模式均为机构节省了大量费用,但由于未考虑门诊护理人员提供的未得到补偿的支持,这些节省的费用通常被高估了。