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盆腔器官脱垂的解剖病理学研究:在卡南加市两家医院开展的大规模活动期间对刚果女性圆韧带和子宫骶韧带的分析研究

Anatomo-pathological aspects of pelvic organ prolapse: analytical study of round and utero-sacral ligaments of Congolese women during the mass campaign in two hospitals of city of Kananga.

作者信息

Kayembe Antoine Tshimbundu, Muyayalo Patrick Kahindo, Muela Andy Mbangama, Tozin Rahma Raschid

机构信息

Department of Gynaecology and Obstetrics, Faculty of Medicine, University Notre-Dame of Kasayi, Central Kasaï, Democratic Republic of Congo.

Department of Gynaecology and Obstetrics, Faculty of Medicine, University of Kinshasa, Kinshasa, Democratic Republic of Congo.

出版信息

Pan Afr Med J. 2025 Jan 14;50:26. doi: 10.11604/pamj.2025.50.26.45534. eCollection 2025.

DOI:10.11604/pamj.2025.50.26.45534
PMID:40322323
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12049147/
Abstract

INTRODUCTION

pelvic organ prolapse is the falling into or out of the vaginal cavity of the uterus or rectum or bladder lined with vaginal walls due to several lesions of the ligaments and fascia of the pelvic floor marked by their weakening or hypotonia. The objective of our present study is to determine the anatomo-pathological aspects associated with pelvic organ prolapse during the surgical care campaign in the hospitals of Bon-Berger and of Saint-Georges of the city of Kananga in the Democratic Republic of Congo.

METHODS

this is an analytical study based on the morphological anatomo-pathological examination of the round and uterosacral ligaments of 100 consenting patients divided into two groups with and without pelvic organ prolapse treated in the Gynecology Departments of Bon-Berger hospitals in Tshikaji and Saint-Georges in Katoka in the city of Kananga, from January 1 to July 31, 2023. Non-probability convenience sampling helped in the selection of cases. The Anova test and the Chi test are used in statistical analyses.

RESULTS

the average age of our patients with pelvic organ prolapse was 57.18 (SD: 8.17) years and their average parity was 7.76 (SD: 1.04) delivery. This average parity was significantly increased compared to those of patients without prolapse. Fibrosis was present in 92% of cases of pelvic organ prolapses, congestion in 62%, inflammatory infiltrate in 54%, and smooth muscle in 22% of cases; the comparison of patients with pelvic organ prolapse to those without prolapse did not find statistically significant differences between these two groups concerning the presence of fibrosis, congestion, the inflammatory infiltrate, and smooth muscle.

CONCLUSION

pelvic organ prolapse is a fibrotic and inflammatory disease not significant and the search for inflammatory and fibrotic markers is essential in our city of Kananga in Democratic Republic of Congo.

摘要

引言

盆腔器官脱垂是指由于盆底韧带和筋膜的多种病变,以其松弛或张力减退为特征,导致子宫、直肠或膀胱沿阴道壁坠入或脱出阴道腔。我们目前这项研究的目的是确定在刚果民主共和国卡南加市的邦 - 贝热医院和圣乔治医院开展的外科治疗活动期间,与盆腔器官脱垂相关的解剖病理学特征。

方法

这是一项分析性研究,基于对100例自愿参与的患者的圆韧带和子宫骶韧带进行形态解剖病理学检查。这些患者分为两组,分别是有盆腔器官脱垂和无盆腔器官脱垂的患者,于2023年1月1日至7月31日在卡南加市奇卡吉的邦 - 贝热医院和卡托卡的圣乔治医院的妇科接受治疗。采用非概率方便抽样法选取病例。统计分析使用方差分析和卡方检验。

结果

我们患有盆腔器官脱垂的患者平均年龄为57.18(标准差:8.17)岁,平均产次为7.76(标准差:1.04)次分娩。与无脱垂患者相比,这一平均产次显著增加。在92%的盆腔器官脱垂病例中存在纤维化,62%有充血,54%有炎性浸润,22%有平滑肌;在纤维化、充血、炎性浸润和平滑肌的存在方面,将有盆腔器官脱垂的患者与无脱垂的患者进行比较,未发现这两组之间存在统计学显著差异。

结论

盆腔器官脱垂是一种纤维化和炎症性疾病,差异不显著,在刚果民主共和国的卡南加市寻找炎症和纤维化标志物至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0c7/12049147/5a1cc90556dd/PAMJ-50-26-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0c7/12049147/5cf8a803fd3c/PAMJ-50-26-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0c7/12049147/5a1cc90556dd/PAMJ-50-26-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0c7/12049147/5cf8a803fd3c/PAMJ-50-26-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0c7/12049147/5a1cc90556dd/PAMJ-50-26-g002.jpg

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本文引用的文献

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Factors associated with pelvic organ prolapse: case-control study in two hospitals of Bon-Berger and Saint Georges of the city of Kananga in the Democratic Republic of the Congo.与盆腔器官脱垂相关的因素:刚果民主共和国金沙萨博恩-贝格尔和圣乔治市两家医院的病例对照研究。
Pan Afr Med J. 2024 Jun 27;48:76. doi: 10.11604/pamj.2024.48.76.43545. eCollection 2024.
2
Pelvic organ prolapse: a cross-sectional study during mass campaign in two hospitals in the city of Kananga in the Democratic Republic of Congo.盆腔器官脱垂:刚果民主共和国卡南加市两家医院大规模筛查期间的一项横断面研究。
Pan Afr Med J. 2024 Feb 8;47:52. doi: 10.11604/pamj.2024.47.52.42470. eCollection 2024.
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Potential molecular targets for intervention in pelvic organ prolapse.
盆腔器官脱垂干预的潜在分子靶点。
Front Med (Lausanne). 2023 Sep 5;10:1158907. doi: 10.3389/fmed.2023.1158907. eCollection 2023.
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Expression of CD44, Transforming Growth Factor-β, and Matrix Metalloproteinases in Women With Pelvic Organ Prolapse.盆腔器官脱垂女性中CD44、转化生长因子-β和基质金属蛋白酶的表达
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Factors associated with genital prolapse to Saint Joseph Hospital of Kinshasa.与金沙萨圣约瑟夫医院的生殖器脱垂相关的因素。
Pan Afr Med J. 2021 Dec 16;40:234. doi: 10.11604/pamj.2021.40.234.30529. eCollection 2021.
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The polymorphisms of extracellular matrix-remodeling genes are associated with pelvic organ prolapse.细胞外基质重塑基因的多态性与盆腔器官脱垂有关。
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Structural, functional and molecular pathogenesis of pelvic organ prolapse in patient and deficient mice.盆腔器官脱垂患者和缺陷小鼠的结构、功能和分子发病机制。
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