Wang Zhen, Qu Yilin, Wang Hua, Wang Chunxiao
Department of Cardiology, Yantai Yuhuangding Hospital of Qingdao University, Yantai, People's Republic of China.
Department of Medical Records, Yantai Yuhuangding Hospital of Qingdao University, Yantai, People's Republic of China.
J Inflamm Res. 2025 Apr 30;18:5821-5833. doi: 10.2147/JIR.S518233. eCollection 2025.
To evaluate the relationship between the HALP Index and the recurrence of persistent atrial fibrillation (AF) following radiofrequency catheter ablation (RFCA).
We retrospectively analyzed 471 patients with persistent AF treated with RFCA between January 2019 and June 2022 at Yantai Yuhuangding Hospital of Qingdao University. The relationship between the Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Index and AF recurrence outcomes was assessed using Kaplan-Meier survival curve analysis and multifactorial Cox proportional hazards regression modeling. Receiver operating characteristic (ROC) curves were generated to evaluate the predictive value of the HALP Index for recurrence in patients with persistent AF undergoing RFCA.
After a mean follow-up of 43.6 months, recurrence occurred in 130 patients (27.6%). There was a significant difference in the recurrence rate after RFCA of AF among the different HALP Index groups (44.9% vs 26.3% vs 22.9% vs 16.2%, F = 9.347, P < 0.001). Multifactorial Cox proportional hazards regression analysis indicated that the HALP Index was significantly associated with recurrence after RFCA of AF (HR = 0.967, P < 0.001). The HALP Index was treated as a categorical variable in the multifactorial Cox proportional hazards regression analysis, which revealed that the recurrence rate of RFCA of AF was significantly higher in the low HALP Index group compared to the high HALP Index group (HR = 6.080, P < 0.001). The results of the Kaplan-Meier survival analyses suggested a significant difference in recurrence after RFCA of AF among the various HALP Index groups (Log-rank P < 0.001). The ROC curve analysis demonstrated the predictive value of the HALP Index for recurrence after RFCA of AF, with an area under the curve (AUC) of 0.659 (95% CI 0.603-0.715, P < 0.001).
The HALP Index was an independent protective predictor of recurrence following RFCA of persistent AF.
评估血红蛋白、白蛋白、淋巴细胞和血小板（HALP）指数与射频导管消融（RFCA）后持续性心房颤动（AF）复发之间的关系。
我们回顾性分析了2019年1月至2022年6月在青岛大学烟台毓璜顶医院接受RFCA治疗的471例持续性AF患者。使用Kaplan-Meier生存曲线分析和多因素Cox比例风险回归模型评估HALP指数与AF复发结局之间的关系。绘制受试者工作特征（ROC）曲线以评估HALP指数对接受RFCA的持续性AF患者复发的预测价值。
平均随访43.6个月后，130例患者（27.6%）出现复发。不同HALP指数组AF射频消融术后的复发率存在显著差异（44.9%对26.3%对22.9%对16.2%，F = 9.347，P < 0.001）。多因素Cox比例风险回归分析表明，HALP指数与AF射频消融术后的复发显著相关（HR = 0.967，P < 0.001）。在多因素Cox比例风险回归分析中，HALP指数被视为分类变量，结果显示低HALP指数组AF射频消融术的复发率显著高于高HALP指数组（HR = 6.080，P < 0.001）。Kaplan-Meier生存分析结果表明，不同HALP指数组AF射频消融术后的复发存在显著差异（对数秩P < 0.001）。ROC曲线分析证明了HALP指数对AF射频消融术后复发的预测价值，曲线下面积（AUC）为0.659（95%CI 0.603 - 0.715，P < 0.001）。
HALP指数是持续性AF射频消融术后复发的独立保护性预测指标。
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