Yang Shao-Bing, Zhao Hong-Wei
Department of Cardiology, The General Hospital of Ningxia Medical University, Yinchuan, People's Republic of China.
Department of Cardiology, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, People's Republic of China.
J Inflamm Res. 2025 Jan 3;18:61-71. doi: 10.2147/JIR.S500743. eCollection 2025.
Inflammation was associated with the increased risk of atrial fibrillation (AF). As a novel inflammatory indicator, albumin/neutrophil-to-lymphocyte ratio score (ANS) has been demonstrated to associate with coronary artery disease. However, the relationship between ANS and new onset atrial fibrillation (NOAF) in patients with acute myocardial infarction (AMI) underwent PCI was not determined.
A total of 2410 AMI patients underwent PCI were consecutively included between March 2020 and December 2023. Patients were divided into NOAF group and control group according to the occurrence of NOAF during hospitalization. The ANS was calculated and analyzed, so as to determine its predictive value in the presence of NOAF in AMI patients after PCI.
In total, 88 (3.7%) individuals developed NOAF during hospitalization. We found that NOAF was associated with older age, greater LA, higher NT-proBNP, ANS and Killip ≥ 2. The ANS exhibited an accurately predictive value for the NOAF (area under the curve [AUC], 0.695; 95% CI, 0.649-0.740, P < 0.001). Moreover, when divided into three groups according to the tertile of ANS, patients in tertile 1 (lowest in ANS) showed a 2.214-fold increased risk of NOAF in comparison to those in the tertile 3 (HR, 2.214; 95% CI 1.804-5.101; P = 0.029).
ANS is a robust tool for the prediction of NOAF in AMI patients underwent PCI. Therefore ANS could be used for risk prediction and optimal management for NOAF in AMI patients after PCI.
炎症与心房颤动（AF）风险增加相关。作为一种新型炎症指标，白蛋白/中性粒细胞与淋巴细胞比值评分（ANS）已被证明与冠状动脉疾病有关。然而，急性心肌梗死（AMI）接受经皮冠状动脉介入治疗（PCI）患者中ANS与新发心房颤动（NOAF）之间的关系尚未确定。
连续纳入2020年3月至2023年12月期间接受PCI的2410例AMI患者。根据住院期间是否发生NOAF将患者分为NOAF组和对照组。计算并分析ANS，以确定其对PCI术后AMI患者发生NOAF的预测价值。
共有88例（3.7%）患者在住院期间发生NOAF。我们发现，NOAF与年龄较大、左心房较大、N末端脑钠肽前体（NT-proBNP）较高、ANS以及Killip分级≥2有关。ANS对NOAF具有准确的预测价值（曲线下面积[AUC]为0.695；95%可信区间[CI]为0.649 - 0.740，P < 0.001）。此外，根据ANS三分位数分为三组时，与三分位数3的患者相比，三分位数1（ANS最低）的患者发生NOAF的风险增加2.214倍（风险比[HR]为2.214；95% CI为1.804 - 5.101；P = 0.029）。
ANS是预测PCI术后AMI患者发生NOAF的有力工具。因此，ANS可用于PCI术后AMI患者NOAF的风险预测和优化管理。
