对具有CYP-17α-羟化酶的植物化学物质的分析。 （你提供的原文似乎不完整，from后面缺少具体内容）
analysis of phytochemicals from with cyp-17α-hydroxylase enzyme.
作者信息
Balasubramaniyan Saraswathi, Annamalai Siva, Ravichandran Deepa, Balasubramaniam Vinu Bharathi, Ramamoorthy Vinodini, Shenbagaraj Shunmugaram
机构信息
Department of Siddha Physician, Om Muruga Siddha Clinic, Thanjavur, Tamil Nadu-613006, India.
Department of Research Associate (S)-II, Siddha Regional Research Institute, Puducherry-13, India.
出版信息
Bioinformation. 2025 Feb 28;21(2):274-281. doi: 10.6026/973206300210274. eCollection 2025.
Polycystic ovarian syndrome (PCOS) affects 9.2% of women of reproductive age and has doubled in prevalence, rising from 6 million cases in 1990 to 12.13 million in 2019. PCOS is characterized by symptoms like irregular periods, acne, hirsutism, male-pattern baldness, weight gain, mood swings and infertility. PCOS is primarily associated with elevated androgen levels. The use of Indian for managing PCOS is well documented. Therefore, it is of interest to report the analysis of phytochemicals from Indian with cyp-17α-hydroxylase enzyme (CYP17). Analysis shows that phytochemicals such as gingerenone A, chlorogenic acid and piperine present in exhibit strong binding affinities to the enzyme suggesting their potential as CYP17 inhibitors for further validation and consideration.
多囊卵巢综合征（PCOS）影响9.2%的育龄妇女，其患病率已翻了一番，从1990年的600万例增至2019年的1213万例。PCOS的特征包括月经不规律、痤疮、多毛症、男性型秃发、体重增加、情绪波动和不孕。PCOS主要与雄激素水平升高有关。印度草药用于管理PCOS已有充分记载。因此，报告对印度草药中与cyp - 17α - 羟化酶（CYP17）相关的植物化学物质的分析很有意义。分析表明，印度草药中存在的姜烯酮A、绿原酸和胡椒碱等植物化学物质对该酶表现出很强的结合亲和力，表明它们有潜力作为CYP17抑制剂用于进一步验证和考量。
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