Matthews C J, Adams A M, Searle R F
J Reprod Immunol. 1985 Jun;7(4):315-23. doi: 10.1016/0165-0378(85)90026-9.
A mouse macrophage-specific rat monoclonal antibody, F4/80, has been used to detect directly macrophages in short term cultures of mouse decidua, fetal placenta and yolk sac and to investigate the identity of Fc receptor (FcR) bearing cells in these tissues. We find that a significant proportion of FcR positive cells in decidual, placental and yolk sac tissues are macrophages as defined by the expression of the macrophage marker, F4/80 antigen. Macrophages may act as immunocompetent cells near to the maternal-fetal interface and play a significant role in the mechanism of the transfer of passive immunity from mother to fetus across the mouse yolk sac.
一种小鼠巨噬细胞特异性大鼠单克隆抗体F4/80，已被用于在小鼠蜕膜、胎儿胎盘和卵黄囊的短期培养物中直接检测巨噬细胞，并研究这些组织中携带Fc受体（FcR）的细胞的特性。我们发现，蜕膜、胎盘和卵黄囊组织中相当一部分FcR阳性细胞是巨噬细胞，这是由巨噬细胞标志物F4/80抗原的表达所定义的。巨噬细胞可能作为母胎界面附近的免疫活性细胞，在小鼠卵黄囊介导的母体被动免疫向胎儿转移机制中发挥重要作用。
