Wood G W
Placenta. 1980 Oct-Dec;1(4):309-17. doi: 10.1016/s0143-4004(80)80032-4.
Several studies have indicated the presence of mononuclear phagocytes in placentae and in extra-placental membranous structures from various mammalian species, but little is known of the cells' precise location or of their possible functions. Because localization of macrophages in mice is facilitated by the existence of specific antisera, indirect immunofluorescence was used in the present study to identify and approximate the numbers of macrophages associated with murine placentae, yolk-sac membranes and pregnant uteri. Substantial numbers of cells which were reactive with the specific antiserum were observed in uterine tissue, in the uterine cavity and in the mesodermal layer of the yolk sac. There was no readily apparent quantitative relationship between macrophages in either location and antigenic disparity between mother and fetus. Furthermore, the macrophages contained substantial amounts of immunoglobulin, apparently in the form of antigen-antibody complexes, an observation which suggested that those Fc receptor-positive cells may function to remove complexes of soluble fetal antigen and anti-fetal antibody during passage of immunoglobulin from mother to fetus.
多项研究表明，在各种哺乳动物物种的胎盘和胎盘外膜结构中存在单核吞噬细胞，但对于这些细胞的确切位置或其可能的功能知之甚少。由于存在特异性抗血清有助于在小鼠中定位巨噬细胞，因此在本研究中使用间接免疫荧光来鉴定和估算与小鼠胎盘、卵黄囊膜和妊娠子宫相关的巨噬细胞数量。在子宫组织、子宫腔和卵黄囊的中胚层中观察到大量与特异性抗血清反应的细胞。在这两个位置的巨噬细胞与母胎之间的抗原差异之间没有明显的定量关系。此外，巨噬细胞含有大量免疫球蛋白，显然是以抗原 - 抗体复合物的形式存在，这一观察结果表明，那些Fc受体阳性细胞可能在免疫球蛋白从母体传递到胎儿的过程中发挥作用，清除可溶性胎儿抗原和抗胎儿抗体的复合物。
