Wolfe F, Hawley D J
J Rheumatol. 1985 Apr;12(2):245-52.
Four hundred and fifty-eight patients whose clinical data had been prospectively entered into a rheumatic disease databank were studied for remission utilizing remission criteria of the American Rheumatism Association and criteria modified for chart review. During the period of observation 86 of 458 or 18.8% had at least one remission by investigators' assessment on chart review and 18.1% by application of ARA criteria. Patients were followed for 1131 patient years and remission occupied 97 patient years. For patients achieving remission this period represented 34.5% of their followup duration. The median length of remission was 10 months. Nineteen (18.6) percent of gold treatment courses and 16.7% of penicillamine courses resulted in remission. Fourteen (13.6) percent of patients who never received remittive therapy also had remissions. The ARA Preliminary Criteria for Clinical Remission in Rheumatoid Arthritis displayed a sensitivity of 80.2% and a specificity of 96.2% in this population. In patients receiving remittive therapy, female sex, disease onset before age 60, and early development of erosions were associated with decreased proportion of remission.
对458例临床资料已前瞻性录入风湿性疾病数据库的患者，采用美国风湿病协会的缓解标准及为图表回顾修改后的标准研究缓解情况。在观察期内，根据研究者对图表回顾的评估，458例中的86例（18.8%）至少有一次缓解，应用美国风湿病协会标准则为18.1%。对患者随访了1131患者年，缓解期占97患者年。对于达到缓解的患者，该时间段占其随访时长的34.5%。缓解的中位时长为10个月。19%（18.6）的金制剂治疗疗程和16.7%的青霉胺疗程导致缓解。14%（13.6）从未接受缓解治疗的患者也有缓解情况。类风湿关节炎临床缓解的美国风湿病协会初步标准在该人群中的敏感性为80.2%，特异性为96.2%。在接受缓解治疗的患者中，女性、60岁前发病以及早期出现侵蚀与缓解比例降低相关。
