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脑室镜联合Ommaya贮液器植入术治疗具有神经囊尾蚴病非典型神经影像学特征的脑积水:一例报告

Ventriculoscopy combined with Ommaya reservoir implantation for treatment of hydrocephalus with atypical neuroimaging features of neurocysticercosis: A case report.

作者信息

Chen Qiang, Shao Qiang, Chen Lang

机构信息

Department of Neurosurgery, General Hospital of Yangtze River Shipping, Wuhan Brain Hospital, Wuhan, Hubei Province, China.

出版信息

Medicine (Baltimore). 2025 May 2;104(18):e42320. doi: 10.1097/MD.0000000000042320.

DOI:10.1097/MD.0000000000042320
PMID:40324233
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12055087/
Abstract

RATIONALE

Cysticercosis-induced hydrocephalus presents diagnostic and therapeutic challenges owing to its heterogeneous clinical manifestations. Acute hydrocephalus secondary to parasitic infections of the central nervous system (CNS) requires tailored surgical interventions to address impaired cerebrospinal fluid (CSF) dynamics and intracranial hypertension.

PATIENT CONCERNS

A 27-year-old male reported intermittent dizziness and headaches persisting for 3 years and a recent onset of vomiting over the past month.

DIAGNOSES

Neuroimaging demonstrated ventricular enlargement, thickened basal membranes, and elevated intracranial pressure, without classical cysticercosis imaging markers. Serological and CSF enzyme-linked immunosorbent assay (ELISA) tests confirmed the presence of antibodies against cysticercosis. The patient was diagnosed with acute exacerbation of chronic hydrocephalus secondary to a CNS cysticercosis infection complicated by extensive ependymitis and CSF absorption dysfunction.

INTERVENTIONS

Ventriculoscopy identified impaired CSF circulation caused by ependymitis, precluding conventional ventriculoperitoneal (V-P) shunts or endoscopic third ventriculostomy. An Ommaya reservoir was implanted to regulate intracranial pressure, which was supplemented by antiparasitic therapy with praziquantel.

OUTCOMES

Postoperative follow-up confirmed resolution of hydrocephalus and complete alleviation of neurological symptoms, with no complications observed.

LESSONS

This case highlights ventriculoscopy-guided Ommaya reservoir implantation as a safe and effective alternative for managing parasitic infection-induced hydrocephalus when standard surgical options are contraindicated. This strategy addresses both CSF dynamics and infection and provides a reference for managing atypical neurocysticercosis cases.

摘要

理论依据

囊尾蚴病所致脑积水因其临床表现多样,在诊断和治疗方面存在挑战。中枢神经系统(CNS)寄生虫感染继发的急性脑积水需要针对性的手术干预,以解决脑脊液(CSF)动力学受损和颅内高压问题。

患者情况

一名27岁男性报告间歇性头晕和头痛持续3年,近1个月出现呕吐。

诊断

神经影像学显示脑室扩大、基底膜增厚和颅内压升高,无典型囊尾蚴病影像学标志物。血清学和脑脊液酶联免疫吸附试验(ELISA)检测证实存在抗囊尾蚴病抗体。该患者被诊断为CNS囊尾蚴病感染继发慢性脑积水急性加重,并发广泛室管膜炎和脑脊液吸收功能障碍。

干预措施

脑室镜检查发现室管膜炎导致脑脊液循环受损,排除了传统的脑室腹腔(V-P)分流术或内镜下第三脑室造瘘术。植入了一个Ommaya储液囊来调节颅内压,并辅以吡喹酮抗寄生虫治疗。

结果

术后随访证实脑积水消退,神经症状完全缓解,未观察到并发症。

经验教训

该病例强调了在标准手术选择禁忌时,脑室镜引导下植入Ommaya储液囊是治疗寄生虫感染所致脑积水的一种安全有效的替代方法。这种策略既能解决脑脊液动力学问题,又能治疗感染,为处理非典型神经囊尾蚴病病例提供了参考。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3d6/12055087/dd38bd889824/medi-104-e42320-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3d6/12055087/d64f8289fd2c/medi-104-e42320-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3d6/12055087/dd38bd889824/medi-104-e42320-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3d6/12055087/d64f8289fd2c/medi-104-e42320-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3d6/12055087/dd38bd889824/medi-104-e42320-g002.jpg

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本文引用的文献

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Nat Med. 2024 Dec;30(12):3522-3533. doi: 10.1038/s41591-024-03275-1. Epub 2024 Nov 12.
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Clinical application and evaluation of metagenomic next-generation sequencing in pathogen detection for suspected central nervous system infections.
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Sci Rep. 2024 Jul 23;14(1):16961. doi: 10.1038/s41598-024-68034-1.
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Top-50 cited articles on cysticercosis and neurocysticercosis.关于囊虫病和脑囊虫病的前 50 篇高引文献
Medicine (Baltimore). 2024 Mar 1;103(9):e37268. doi: 10.1097/MD.0000000000037268.
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Effects of modified external ventricular drainage vs. an Ommaya reservoir in the management of hydrocephalus with intracranial infection in pediatric patients.改良外引流术与Ommaya贮液器在小儿颅内感染性脑积水治疗中的效果比较
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Neurocysticercosis mimicking craniopharyngioma: A case report.酷似颅咽管瘤的神经囊尾蚴病:一例报告
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Intraventricular migration of fourth ventricular neurocysticercosis: an unusual complication during endoscopic surgery.第四脑室神经囊尾蚴病的脑室内迁移:内镜手术中的一种不常见并发症。
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