Thompson Katie D, Leinninger Gina M
Neuroscience Program, Michigan State University, East Lansing, MI, 48824, USA.
Neuroscience Program, Michigan State University, East Lansing, MI, 48824, USA; Department of Physiology, Michigan State University, East Lansing, MI, 48824, USA.
Neuropharmacology. 2025 Sep 1;275:110496. doi: 10.1016/j.neuropharm.2025.110496. Epub 2025 May 3.
Neurotensin (Nts) is a peptide that acts via neurotensin receptors and is implicated in multiple aspects of physiology and behavior, including modulating feeding and body weight. How and where the Nts signaling system mediates these effects, and via which of its receptor isoforms is incompletely understood. This review examines the role of Nts signaling via the periphery and central nervous system on feeding and body weight. These data highlight various ways in which the Nts system contributes to feeding and body weight that differ depending on the site, tissue, and the Nts or Nts receptor-expressing cell type in question. Given that the Nts system does not convey the same signaling throughout the body, constitutive approaches modulating the expression or signaling of the Nts signaling system may not provide sufficient resolution to reveal how it impacts feeding. Combining neuropharmacology and site-specific approaches holds promise define the broad range of mechanisms by the Nts system modulates feeding and satiety and its contributions to normal and disrupted feeding states.
神经降压素（Nts）是一种通过神经降压素受体发挥作用的肽，参与生理和行为的多个方面，包括调节进食和体重。Nts信号系统如何以及在何处介导这些效应，以及通过其哪种受体亚型介导，目前尚不完全清楚。本综述探讨了Nts信号通过外周和中枢神经系统对进食和体重的作用。这些数据突出了Nts系统以多种方式影响进食和体重，这些方式因所涉及的部位、组织以及表达Nts或Nts受体的细胞类型而异。鉴于Nts系统在全身传递的信号并不相同，调节Nts信号系统表达或信号的组成性方法可能无法提供足够的分辨率来揭示其如何影响进食。结合神经药理学和位点特异性方法有望确定Nts系统调节进食和饱腹感的广泛机制及其对正常和紊乱进食状态的作用。
