Han Xiangping, He Lei, Li Shaoying, Zhu Yuxing
Department of Oncology II, Zhumadian Central Hospital, No. 747, West Section of Zhonghua Road, Yicheng District, Zhumadian City, 463000, Henan, China.
Third Department of Psychological Medicine, Zhumadian Second People's Hospital, No. 51 Xuesong Road, Zhumadian City, 463000, Henan Province, China.
Sci Rep. 2025 May 5;15(1):15682. doi: 10.1038/s41598-025-00317-7.
This study investigates trends in liver cancer rehabilitation needs, disease burden, and attributable risk factors in China from 1990 to 2021 using data from the Global Burden of Disease Study 2021. Key metrics included age-standardized prevalence (ASPR), years lived with disability (YLDs), and risk factor attribution. Between 1990 and 2021, the number of liver cancer patients requiring rehabilitation surged by 100.1% (132,779 to 265,539 cases), with YLDs rising by 102.8% (22,981 to 46,602). While ASPR and age-standardized YLD rates (ASYR) showed modest declines (ASPR: - 0.1% annual change; ASYR: - 0.23%), males exhibited a disproportionately higher burden, with 2021 cases and YLDs 2.98- and 2.74-fold greater than females, respectively. Risk factor analysis revealed smoking (14.0%), drug use (11.5%), and alcohol consumption (11.4%) as primary contributors, while metabolic factors like high BMI (7.5%) and fasting plasma glucose (1.9%) demonstrated accelerating impacts (YLDs EAPC: + 4.47% and + 1.31%, respectively). Aging populations and shifting etiologies drove increased rehabilitation demands, particularly among those ≥ 80 years. These findings underscore urgent needs for gender-specific interventions targeting modifiable risks and integrated nursing rehabilitation strategies to mitigate China's growing liver cancer burden.
本研究利用《2021年全球疾病负担研究》的数据，调查了1990年至2021年中国肝癌康复需求、疾病负担及可归因风险因素的趋势。关键指标包括年龄标准化患病率（ASPR）、伤残调整生命年（YLDs）和风险因素归因。1990年至2021年期间，需要康复的肝癌患者数量激增100.1%（从132,779例增至265,539例），YLDs增加了102.8%（从22,981增至46,602）。虽然ASPR和年龄标准化YLD率（ASYR）略有下降（ASPR：年变化-0.1%；ASYR：-0.23%），但男性的负担 disproportionately 更高，2021年的病例数和YLDs分别是女性的2.98倍和2.74倍。风险因素分析显示，吸烟（14.0%）、吸毒（11.5%）和饮酒（11.4%）是主要因素，而高BMI（7.5%）和空腹血糖（1.9%）等代谢因素的影响正在加速（YLDs的EAPC分别为+4.47%和+1.31%）。人口老龄化和病因变化导致康复需求增加，尤其是在80岁及以上人群中。这些发现强调了针对可改变风险的针对性别干预措施以及综合护理康复策略的迫切需求，以减轻中国日益增长的肝癌负担。
