Sun Haoyu, Deng Han, Liu Yixi, He Zitian, Liu Gongyue, Chen Zhong, Huang Xiande, Chen Gang, Li Yan, Huang Hai, Tang Jin, Pang Lei, Liu Tao, Luo Deyi, Zhang Mengyang, Chen Hui, Liao Limin, Li Xing
School of Rehabilitation, Capital Medical University, Beijing, China.
Department of Urology, China Rehabilitation Research Centre, Beijing, China.
Sci Rep. 2025 May 5;15(1):15718. doi: 10.1038/s41598-025-00621-2.
This study aimed to investigate common complications during the chronic phase of spinal cord injury (SCI) and to assess bladder management methods and their associated complications in patients with neurogenic lower urinary tract dysfunction (NLUTD). A retrospective analysis was performed using clinical data from chronic-phase SCI patients across multiple centers in China. The study population included individuals diagnosed with SCI and admitted between January 1, 2017, and December 31, 2022. Chi-square tests were used to evaluate differences in the distribution of complications, disease duration, bladder management methods, and urinary complications. Univariate and multivariate analyses were conducted to identify risk factors for urinary complications. A total of 849 SCI patients from 28 provinces in China were included, showing significant demographic and clinical differences between traumatic SCI (TSCI) and non-traumatic SCI (NTSCI). Urinary tract infection (59.95%) and bowel-related complications, such as constipation (62.17%), were the most frequently reported complications. Additionally, the incidences of osteoporosis (38.50%), neuropathic pain (29.99%), bowel incontinence (12.06%), and hydronephrosis (11.91%) were also high. NLUTD was present in 90.58% of SCI patients. Among these, intermittent catheterization was associated with significantly lower rates of urological complications compared to indwelling catheterization (p = 0.025). Multivariate analysis identified bladder management method as a significant risk factor for urinary complications, with indwelling catheterization associated with a higher risk of urinary stones (p < 0.001) compared to intermittent catheterization. The high prevalence of bowel- and urological-related complications among Chinese SCI patients highlights the need for increased societal attention. In terms of bladder management, intermittent catheterization may provide greater benefits compared to indwelling catheterization. Further research and education are necessary to promote intermittent catheterization as a standardized bladder management approach for SCI patients.
本研究旨在调查脊髓损伤(SCI)慢性期的常见并发症,并评估神经源性下尿路功能障碍(NLUTD)患者的膀胱管理方法及其相关并发症。利用来自中国多个中心的慢性期SCI患者的临床数据进行回顾性分析。研究人群包括2017年1月1日至2022年12月31日期间被诊断为SCI并入院的个体。采用卡方检验评估并发症分布、病程、膀胱管理方法和泌尿系统并发症的差异。进行单因素和多因素分析以确定泌尿系统并发症的危险因素。共纳入了来自中国28个省份的849例SCI患者,创伤性SCI(TSCI)和非创伤性SCI(NTSCI)之间在人口统计学和临床特征上存在显著差异。尿路感染(59.95%)和肠道相关并发症,如便秘(62.17%),是报告最多的并发症。此外,骨质疏松症(38.50%)、神经性疼痛(29.99%)、大便失禁(12.06%)和肾积水(11.91%)的发生率也较高。90.58%的SCI患者存在NLUTD。其中,与留置导尿相比,间歇性导尿的泌尿系统并发症发生率显著较低(p = 0.025)。多因素分析确定膀胱管理方法是泌尿系统并发症的一个重要危险因素,与间歇性导尿相比,留置导尿与尿路结石的风险更高相关(p < 0.001)。中国SCI患者中肠道和泌尿系统相关并发症的高患病率凸显了社会需要更多关注。在膀胱管理方面,与留置导尿相比,间歇性导尿可能带来更大益处。有必要进行进一步的研究和教育,以推广间歇性导尿作为SCI患者标准化的膀胱管理方法。