de Guimaraes Thales A C, Kalitzeos Angelos, Bainbridge James, Michaelides Michel
UCL Institute of Ophthalmology, University College London, London, UK.
Moorfields Eye Hospital NHS Foundation Trust, London, UK.
Transl Vis Sci Technol. 2025 May 1;14(5):9. doi: 10.1167/tvst.14.5.9.
The purpose of this study was to describe a method to determine the position of the preferred retinal locus (PRL).
Cross-sectional data were obtained prospectively. Microperimetry was completed with the Macular Integrity Assessment (MAIA) under mesopic testing conditions. Spectral domain optical coherence tomography (SD-OCT) was acquired with the Spectralis SD-OCT system. The printout of the MAIA containing the PRL and both the horizontal and vertical transfoveal scans were interpolated in Adobe Photoshop, which was used to calculate the foveal center (FC) and to create a custom ruler to measure the distance from the foveal center (DFC) and the distance between PRL (DPRL). The methodology was tested by two independent graders in participants of a natural history study for KCNV2-associated retinopathy.
Twenty-two eyes of 12 subjects were analyzed at a mean age of 31.9 years (range = 11-54 years, SD = ±14.3). The mean DFC and DPRL was 1398 µm (range = 182.8-2896, SD = ±755.4), and 751.4 µm (range = 144.5-1493.3, SD = ±458.3) in the right eyes, and 1104 µm (range = 341.8-2513, SD = ±653.78) and 742.5 µm (range = 120-1918, SD = ±586.5) in the left eyes, respectively. There was no significant interocular correlation of DFC (r = -0.036, P = 0.92) or DPRL (r = 0.41, P = 0.26), or between the two variables in the right (r = 0.519, P = 0.084) and left eyes (r = 0.014, P = 0.97). These suggest that DPRL may not be related to the location of eccentric fixation and that the values of either eye are independent of each other.
Our data suggest that these are reliable parameters, which could be of relevance in the context of clinical trials. The sample size is small and its correlation with other functional and structural outcomes remains to be explored, but these findings provide a framework for further development.
This work bridges the distance between basic science and clinical care by providing a reliable and replicable method to quantify the preferred retinal locus of patients with eccentric fixation.
本研究旨在描述一种确定视网膜首选位点（PRL）位置的方法。
前瞻性地获取横断面数据。在中视测试条件下，使用黄斑完整性评估（MAIA）完成微视野检查。使用Spectralis SD-OCT系统采集光谱域光学相干断层扫描（SD-OCT）图像。将包含PRL以及水平和垂直中央凹扫描的MAIA打印输出在Adobe Photoshop中进行插值，用于计算中央凹中心（FC）并创建自定义标尺以测量距中央凹中心的距离（DFC）和PRL之间的距离（DPRL）。两名独立的评分者在一项关于KCNV2相关性视网膜病变的自然史研究参与者中对该方法进行了测试。
对12名受试者的22只眼睛进行了分析，平均年龄为31.9岁（范围=11 - 54岁，标准差=±14.3）。右眼的平均DFC和DPRL分别为1398 µm（范围=182.8 - 2896，标准差=±755.4）和751.4 µm（范围=144.5 - 1493.3，标准差=±458.3），左眼的平均DFC和DPRL分别为1104 µm（范围=341.8 - 2513，标准差=±653.78）和742.5 µm（范围=120 - 1918，标准差=±586.5）。DFC（r = -0.036，P = 0.92）或DPRL（r = 0.41，P = 0.26）在两眼之间无显著相关性，右眼（r = 0.519，P = 0.084）和左眼（r = 0.014，P = 0.97）的两个变量之间也无显著相关性。这些结果表明DPRL可能与偏心注视的位置无关，且两眼的值相互独立。
我们的数据表明这些是可靠的参数，在临床试验背景下可能具有相关性。样本量较小，其与其他功能和结构结果的相关性仍有待探索，但这些发现为进一步发展提供了框架。
这项工作通过提供一种可靠且可重复的方法来量化偏心注视患者的视网膜首选位点，在基础科学和临床护理之间架起了桥梁。
