Legras Richard, Gaudric Alain, Woog Kelly
Laboratoire Aimé Cotton, CNRS, Université Paris-Sud, ENS Paris-Saclay, Université Paris-Saclay, Orsay, France.
Université Paris Diderot - APHP Hôpital Lariboisière, Paris, France.
PLoS One. 2018 Jan 16;13(1):e0191141. doi: 10.1371/journal.pone.0191141. eCollection 2018.
The aim of this article is to analyse cone density, spacing and arrangement using an adaptive optics flood illumination retina camera (rtx1™) on a healthy population. Cone density, cone spacing and packing arrangements were measured on the right retinas of 109 subjects at 2°, 3°, 4°, 5° and 6° of eccentricity along 4 meridians. The effects of eccentricity, meridian, axial length, spherical equivalent, gender and age were evaluated. Cone density decreased on average from 28 884 ± 3 692 cones/mm2, at 2° of eccentricity, to 15 843 ± 1 598 cones/mm2 at 6°. A strong inter-individual variation, especially at 2°, was observed. No important difference of cone density was observed between the nasal and temporal meridians or between the superior and inferior meridians. However, the horizontal and vertical meridians differed by around 14% (T-test, p<0.0001). Cone density, expressed in units of area, decreased as a function of axial length (r2 = 0.60), but remained constant (r2 = 0.05) when cone density is expressed in terms of visual angle supporting the hypothesis that the retina is stretched during the elongation of the eyeball. Gender did not modify the cone distribution. Cone density was slightly modified by age but only at 2°. The older group showed a smaller density (7%). Cone spacing increased from 6,49 ± 0,42 μm to 8,72 ± 0,45 μm respectively between 2° and 6° of eccentricity. The mosaic of the retina is mainly triangularly arranged (i.e. cells with 5 to 7 neighbors) from 2° to 6°. Around half of the cells had 6 neighbors.
本文旨在使用自适应光学泛光照明视网膜相机（rtx1™）对健康人群分析视锥细胞密度、间距和排列情况。在109名受试者的右眼视网膜上，沿着4条子午线，在离心率2°、3°、4°、5°和6°处测量视锥细胞密度、视锥细胞间距和排列方式。评估了离心率、子午线、眼轴长度、等效球镜度、性别和年龄的影响。视锥细胞密度平均从离心率2°时的28884±3692个视锥细胞/mm²，降至6°时的15843±1598个视锥细胞/mm²。观察到个体间存在强烈差异，尤其是在2°时。在鼻侧和颞侧子午线之间或上侧和下侧子午线之间，未观察到视锥细胞密度有显著差异。然而，水平和垂直子午线相差约14%（t检验，p<0.0001）。以面积为单位表示的视锥细胞密度随眼轴长度增加而降低（r² = 0.60），但当视锥细胞密度以视角表示时保持不变（r² = 0.05），这支持了眼球伸长过程中视网膜被拉伸的假设。性别并未改变视锥细胞分布。视锥细胞密度随年龄略有变化，但仅在2°时。老年组的密度较小（7%）。视锥细胞间距在离心率2°至6°之间分别从6.49±0.42μm增加到8.72±0.45μm。视网膜镶嵌主要呈三角形排列（即细胞有5至7个邻居），范围从2°至6°。约一半的细胞有6个邻居。
