Komiya I, Ishizuka T, Nishio M, Murata S, Esumi Y, Washino T, Matsunaga K, Takaichi M, Yokoshima T
Jpn J Antibiot. 1984 May;37(5):938-49.
The distribution and tissue accumulation of the radioactivity were studied in male rats after the multiple intravenous administration of 14C-MT-141. The distribution and the placental transfer were also studied using pregnant rats or lactating rats after the single intravenous administration of 14C-MT-141. The radioactive concentration in the fetus was low and the radioactivity was distributed almost uniformly through the fetus body. The peak time of the milk level was 2 hours after the administration and the radioactivity in milk decreased gradually thereafter. The milk levels decreased more slowly than the blood levels did. The blood level after the last dose administered daily for 7 days tended to decrease more slowly, when compared with the single administration. However the blood concentration at 48 hours after the last administration was less than 3 times as high as that after the single administration.
在雄性大鼠多次静脉注射14C-MT-141后，研究了放射性的分布和组织蓄积情况。在怀孕大鼠或哺乳大鼠单次静脉注射14C-MT-141后，也研究了其分布和胎盘转运情况。胎儿体内的放射性浓度较低，且放射性几乎均匀分布于胎儿全身。给药后2小时乳汁水平达到峰值，此后乳汁中的放射性逐渐降低。乳汁水平下降的速度比血药浓度下降的速度慢。与单次给药相比，连续7天每日给药最后一剂后的血药水平下降趋势更慢。然而，末次给药后48小时的血药浓度不到单次给药后血药浓度的3倍。
