Cherenack Emily M, Brophy Theodora F, Max Margarita Avila, Graubard-Silebi Alicia, Nogueira Nicholas F, Pan Yue, Westreich Daniel, Topper Elizabeth F, Konkle-Parker Deborah, Rana Aadia, Kassaye Seble G, Sheth Anandi N, Jones Deborah L, Alcaide Maria L
Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, USA.
Department of Medicine, University of Miami Miller School of Medicine, Miami, USA.
AIDS Behav. 2025 May 6. doi: 10.1007/s10461-025-04724-9.
Positive attitudes towards aging (ATA) are associated with better mental and physical health in the general population and with lower depressive symptoms among men living with HIV. Little is known about ATA among women of reproductive age living with HIV (WWH), who often experience premature aging, depression, and chronic pain. This study examined the association of ATA with HIV, physical functioning, and pain among women 19-45 years-of-age. From 2021 to 2022, survey data were collected at baseline from 143 WWH and 39 women without HIV (WWOH) across the southern United States; 94 WWH also completed a six-month follow-up visit. Baseline ATA was compared across HIV status. Among WWH, correlations between ATA, participant factors relevant in prior research (i.e., age, depression, illness), pain, and physical functioning were examined. Regressions examined the association of baseline ATA with physical functioning and pain across visits, including when controlling for potential confounders. Having one or more negative ATA was reported by an equal proportion of WWH (57%) and WWOH (58%). Among WWH, more positive ATA correlated with lower depressive symptoms, better physical functioning, and lower pain at baseline. Lower depressive symptoms correlated with better physical functioning and lower pain at baseline. In regressions, more positive ATA was associated with better physical functioning at baseline and follow-up. A weak association of ATA with pain at baseline was not significant at follow-up or after controlling for depression. Research is warranted to examine how combined interventions to improve ATA, depression, and pain can support well-being among reproductive-aged WWH.
对衰老的积极态度（ATA）与普通人群更好的身心健康以及感染艾滋病毒男性较低的抑郁症状相关。对于感染艾滋病毒的育龄女性（WWH），人们对其ATA了解甚少，她们经常经历早衰、抑郁和慢性疼痛。本研究调查了19至45岁女性中ATA与艾滋病毒、身体功能和疼痛之间的关联。2021年至2022年期间，在美国南部对143名感染艾滋病毒的育龄女性和39名未感染艾滋病毒的女性（WWOH）在基线时收集了调查数据；94名感染艾滋病毒的育龄女性还完成了为期六个月的随访。比较了不同艾滋病毒感染状况下的基线ATA。在感染艾滋病毒的育龄女性中，研究了ATA、先前研究中相关的参与者因素（即年龄、抑郁、疾病）、疼痛和身体功能之间的相关性。回归分析研究了基线ATA与各次随访时的身体功能和疼痛之间的关联，包括在控制潜在混杂因素时的情况。感染艾滋病毒的育龄女性（57%）和未感染艾滋病毒的女性（58%）报告有一个或多个消极ATA的比例相同。在感染艾滋病毒的育龄女性中，更积极的ATA与较低的抑郁症状、更好的身体功能以及基线时较低的疼痛相关。较低的抑郁症状与较好的身体功能和基线时较低的疼痛相关。在回归分析中，更积极的ATA与基线和随访时更好的身体功能相关。ATA与基线时疼痛的微弱关联在随访时或控制抑郁后不显著。有必要开展研究，以探讨改善ATA、抑郁和疼痛的综合干预措施如何能支持育龄感染艾滋病毒女性的健康。
