Hisazumi H, Ueki O, Kumaki O, Naito K, Misaki T
Gan No Rinsho. 1985 May;31(6 Suppl):697-703.
Photodynamic therapy (PDT), in which hematoporphyrin derivative is activated by an argon-dye laser, was performed on 36 superficial tumors using a 400 micron quartz fiber and cystoscope (spot PDT), and also carried out in 7 patients with primary or secondary CIS, 9 patients with secondary CIS associated with TaTl tumors and 2 patients with multiple small tumors, using a motor-driven laser light scattering optic automatically controlled by a computer (total PDT). In spot PDT, for tumors up to 2 cm in size the light intensity should be 300 mW/cm2 for 5 to 10 minutes or more. For the CIS therapy, the light dose used was 10 to 30 Joules/cm2. There has been no recurrence at present in 8 of the 18 patients at a mean follow-up period of 6.6 months. The techniques and problems associated with total PDT are reported.
采用血卟啉衍生物经氩离子染料激光激活的光动力疗法（PDT），使用400微米石英纤维和膀胱镜对36例浅表肿瘤进行了治疗（点状PDT）；还对7例原发性或继发性原位癌患者、9例伴有TaTl肿瘤的继发性原位癌患者以及2例多发性小肿瘤患者，使用由计算机自动控制的电动激光散射光学器件进行了治疗（全PDT）。在点状PDT中，对于直径达2厘米的肿瘤，光强度应为300毫瓦/平方厘米，持续5至10分钟或更长时间。对于原位癌治疗，所用的光剂量为10至30焦耳/平方厘米。在平均随访6.6个月时，18例患者中有8例目前未复发。报告了与全PDT相关的技术和问题。
