[Photodynamic therapy of superficial tumors and carcinoma in situ of the bladder].

Photodynamic therapy (PDT), in which hematoporphyrin derivative is activated by an argon-dye laser, was performed on 36 superficial tumors using a 400 micron quartz fiber and cystoscope (spot PDT), and also carried out in 7 patients with primary or secondary CIS, 9 patients with secondary CIS associated with TaTl tumors and 2 patients with multiple small tumors, using a motor-driven laser light scattering optic automatically controlled by a computer (total PDT). In spot PDT, for tumors up to 2 cm in size the light intensity should be 300 mW/cm2 for 5 to 10 minutes or more. For the CIS therapy, the light dose used was 10 to 30 Joules/cm2. There has been no recurrence at present in 8 of the 18 patients at a mean follow-up period of 6.6 months. The techniques and problems associated with total PDT are reported.