Peng Yong, Jiang Dai-Yi, Yao Shun-Yu, Zhang Xiuli, Kazuo Sugimoto, Liu Jia, Du Miao-Qiao, Lin Lan-Xin, Chen Quan, Jin Hong
Department of Neurology, Affiliated First Hospital of Hunan Traditional Chinese Medical College, Zhuzhou, Hunan 412000, China.; Department of Neurology, Affiliated Provincial Traditional Chinese Medical Hospital of Hunan University of Chinese Medicine, Zhuzhou, Hunan 412000, China..
Department of Neurology, Affiliated First Hospital of Hunan Traditional Chinese Medical College, Zhuzhou, Hunan 412000, China.; Department of Neurology, Affiliated Provincial Traditional Chinese Medical Hospital of Hunan University of Chinese Medicine, Zhuzhou, Hunan 412000, China.
Exp Neurol. 2025 Aug;390:115287. doi: 10.1016/j.expneurol.2025.115287. Epub 2025 May 4.
Parkinson's disease (PD) is a neurodegenerative disorder that commonly occurs in older individuals and clinically manifests as resting tremors, bradykinesia, muscle stiffness, and impaired postural balance. From a genetic perspective, animal models using gene-editing technologies offer distinct advantages in replicating the pathophysiological traits of PD, while also functionally exploring potential treatment targets. In this review, we highlight the available gene- modified animal models related to various mechanisms of PD, including abnormal expression of alpha-synuclein protein, dysfunction of the autophagy-lysosome system, abnormalities in the ubiquitin-proteasome system, and mitochondrial dysfunction. We further discuss their respective strengths, limitations, and prospects, aiming to provide the most up to date information for the application of PD animal models and the advancement of anti-PD drugs.
帕金森病（PD）是一种常见于老年人的神经退行性疾病，临床症状表现为静止性震颤、运动迟缓、肌肉僵硬和姿势平衡受损。从遗传学角度来看，利用基因编辑技术构建的动物模型在复制帕金森病的病理生理特征以及功能性探索潜在治疗靶点方面具有独特优势。在本综述中，我们重点介绍了与帕金森病各种发病机制相关的现有基因修饰动物模型，包括α-突触核蛋白的异常表达、自噬-溶酶体系统功能障碍、泛素-蛋白酶体系统异常以及线粒体功能障碍。我们进一步讨论了它们各自的优势、局限性和前景，旨在为帕金森病动物模型的应用及抗帕金森病药物的研发提供最新信息。
