Pawar Mrudula, Venkatesan Prem, Mysore Satyanarayana, Bhat Guruprasad
Department of Physiotherapy, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Department of Pulmonology, Manipal Hospital, HAL Airport Road, Bangalore, Karnataka, 560017, India.
Eur Arch Otorhinolaryngol. 2025 May 6. doi: 10.1007/s00405-025-09436-3.
Obstructive sleep apnea (OSA), a sleep-related disorder, reports significant clinical consequences, apart from its socioeconomic burden globally. Among the physiotherapeutic treatment options, exercise training is primarily preferred for these patients. In the current systematic review and meta-analysis, we hypothesize that aerobic exercise training could be beneficial in reducing the severity of OSA.
A thorough literature search was carried out from Scopus, PubMed, CINAHL, Cochrane, and Embase databases following the PRISMA guidelines, and eight studies were included. The primary outcome was the apnea hypopnea index (AHI) and secondary outcomes were maximal oxygen consumption, oxygen desaturation index, mean oxygen saturation during sleep, Epworth sleepiness scale, body mass index, and neck circumference. RevMan version 5.4.1 was utilized for analysis.
Meta-analysis involved seven studies that showed that aerobic training significantly improved the AHI with a mean difference of -5.24 and an overall effect of p < 0.00001; and VO with a mean difference of 5.84 and an overall effect of p = 0.03. The other secondary outcomes reported improvement but were not significant.
The current review concludes that there is supporting evidence for the beneficial effects of aerobic exercise training in reducing the severity of obstructive sleep apnea.
CRD42023453316.
阻塞性睡眠呼吸暂停（OSA）是一种与睡眠相关的疾病，除了其在全球范围内造成的社会经济负担外，还会带来严重的临床后果。在物理治疗选择中，运动训练是这些患者的首选。在当前的系统评价和荟萃分析中，我们假设有氧运动训练可能有助于降低OSA的严重程度。
按照PRISMA指南，对Scopus、PubMed、CINAHL、Cochrane和Embase数据库进行了全面的文献检索，纳入了八项研究。主要结局指标是呼吸暂停低通气指数（AHI），次要结局指标是最大耗氧量、氧饱和度下降指数、睡眠期间平均氧饱和度、爱泼华嗜睡量表、体重指数和颈围。使用RevMan 5.4.1版本进行分析。
荟萃分析涉及七项研究，结果显示有氧运动训练显著改善了AHI，平均差值为-5.24，总体效应p < 0.00001；改善了最大耗氧量，平均差值为5.84，总体效应p = 0.03。报告的其他次要结局指标有所改善，但不显著。
当前的综述得出结论，有证据支持有氧运动训练对降低阻塞性睡眠呼吸暂停严重程度具有有益作用。
PROSPERO注册号：CRD42023453316。
