Lorenzo Cristina, Zubiri Cecilia, Zosi Anabella, Miculan Sandro, Neder Daniela, Rocca Ana, Sabban Judith Cohen, Bigliardi Roman, Biasoli Maria Florencia, Manterola Manuela, de Los Angeles Savia Maria, Perez Luis Orlando, Hernández Carlos Ruiz, Weinschelbaum Renata, Soares Ana Cristina Fontenele, Tahan Soraia, Plante Veronica, Boggio Christian, Arcucci Soledad, Monjaraz Erick Toro, Mortarini Maria Alejandra, Arrizabalo Samantha, Saps Miguel
Hospital Sor Maria Ludovica, La Plata, Buenos Aires, Argentina.
Hospital Juan Pedro Garrahan, Buenos Aires, Argentina.
J Pediatr Gastroenterol Nutr. 2025 Jul;81(1):125-130. doi: 10.1002/jpn3.70058. Epub 2025 May 6.
To compare the features of multichannel intraluminal impedance and pH monitoring (MII-pH) tracings in children with cerebral palsy (CP) and children without CP.
Multicenter, retrospective, analytical study. We examined tracings of children aged 1 to 15 years old, evaluated from May 2017 to January 2024. Population included two groups: Group 1 consisted of children with CP, while control group comprised children without CP who had extra-digestive symptoms suggestive of gastroesophageal reflux disease (GERD) but normal MII-pH results. Quantitative data were analyzed using analysis of variance and t tests. Qualitative data were analyzed using contingency tables and chi-square tests.
We studied 245 children. CP group included 110 children with a mean age of 5.71 years (standard deviation [SD] ± 4.24), while control group included 135 children with a mean age of 5.73 years (SD ± 3.39). The CP group had fewer reflux episodes (p = 0.0015), slower mean acid clearance time (p = 0.04), lower mean baseline impedance and mean nocturnal baseline impedance (p = 1.82e-07 and p = 7.50e-07).
Children with CP have fewer reflux episodes and longer acid clearance times compared with children without CP. Prospective studies including esophagogastroduodenoscopy findings are needed to establish MII-pH reference values in children with CP.
比较脑瘫（CP）患儿与非CP患儿的多通道腔内阻抗和pH监测（MII-pH）描记图特征。
多中心、回顾性分析研究。我们检查了2017年5月至2024年1月期间评估的1至15岁儿童的描记图。研究人群包括两组：第1组由CP患儿组成，而对照组由无CP但有提示胃食管反流病（GERD）的消化外症状但MII-pH结果正常的儿童组成。定量数据采用方差分析和t检验进行分析。定性数据采用列联表和卡方检验进行分析。
我们研究了245名儿童。CP组包括110名儿童，平均年龄5.71岁（标准差[SD]±4.24），而对照组包括135名儿童，平均年龄5.73岁（SD±3.39）。CP组的反流发作次数较少（p = 0.0015），平均酸清除时间较慢（p = 0.04），平均基线阻抗和平均夜间基线阻抗较低（p = 1.82×10⁻⁷和p = 7.50×10⁻⁷）。
与非CP患儿相比，CP患儿的反流发作次数较少，酸清除时间较长。需要包括食管胃十二指肠镜检查结果的前瞻性研究来确定CP患儿的MII-pH参考值。
