Razzaq Meo Sofia, Van de Wiele Tom, Defoirdt Tom
Center for Microbial Ecology and Technology (CMET), Department of Biotechnology, Ghent University, Gent, Belgium.
Gut Microbes. 2025 Dec;17(1):2499573. doi: 10.1080/19490976.2025.2499573. Epub 2025 May 7.
Pathogenic are a major cause of infections in both humans and animals, leading to conditions such as severe diarrheal diseases, urinary tract infections, enteritis, and septicemia. To combat bacterial infections, antibiotics are widely utilized. However, the extensive and inappropriate use of antibiotics has fueled the development and spread of antibiotic resistance, posing a significant challenge to the effective treatment of . There is consequently an urgent need to explore alternative therapies to control such infections. This review provides an overview of the recent findings concerning indole signaling in . uses indole as a quorum sensing molecule, and indole signaling has been reported to decrease various virulence factors in pathogenic , including motility, biofilm formation, adherence to host cells, expression of the LEE pathogenicity island, and formation of attaching and effacing lesions. This makes indole signaling an interesting target for the development of new therapeutics in the framework of antivirulence therapy. Both natural and synthetic indole analogues have been explored as potential virulence inhibitors. This alternative approach could be advantageous, as it will exert less selective pressure for resistance development than conventional antibiotics.
病原菌是人类和动物感染的主要原因，可导致严重腹泻疾病、尿路感染、肠炎和败血症等病症。为了对抗细菌感染，抗生素被广泛使用。然而，抗生素的广泛和不当使用助长了抗生素耐药性的发展和传播，对有效治疗构成了重大挑战。因此，迫切需要探索替代疗法来控制此类感染。本综述概述了关于[此处原文缺失具体细菌名称]中吲哚信号传导的最新研究结果。[此处原文缺失具体细菌名称]利用吲哚作为群体感应分子，据报道吲哚信号传导可降低病原菌的各种毒力因子，包括运动性、生物膜形成、对宿主细胞的粘附、LEE致病岛的表达以及紧密黏附损伤的形成。这使得吲哚信号传导成为抗毒力治疗框架下新型治疗药物开发的一个有趣靶点。天然和合成吲哚类似物都已被探索作为潜在的毒力抑制剂。这种替代方法可能具有优势，因为与传统抗生素相比，它对耐药性发展施加的选择压力较小。
