Hu Yonghua, Wei Qinglin, Yu Yang, Li Haiyuan, Chen Hao
The Second Clinical Medical College, Lanzhou University, Lanzhou, China.
First School of Clinical Medicine, Gansu University of Chinese Medicine, Lanzhou, China.
Int J Surg Protoc. 2024 Oct 21;28(4):1-5. doi: 10.1097/SP9.0000000000000029.
Understanding the metastatic risks and patterns of colon cancer is crucial for patient evaluation and decision-making. However, high-quality evidence on colon cancer metastases is lacking. This study aims to conduct a systematic review and meta-analysis to determine the risk of site-specific metastasis and provide a complete profiling of distant metastasis in colon cancer.
This review will include studies reporting the proportion of different-site metastases among colon cancer patients. Clinical trials, follow-up studies, and cross-sectional surveys with English publications are eligible for inclusion. We will search Medline, Embase, Web of Science, and the Cochrane Library from inception to June 2023. Two reviewers will independently screen the title/abstract and full texts of identified records according to the eligibility criteria. Data from eligible studies will be extracted and used for meta-analysis. Meta-analyses will be conducted to estimate the overall proportion of site-specific metastasis. During meta-analyses, two proportions will be analyzed, i.e., the incidence of metastasis and component proportion. We will select the appropriate tools to assess the risk of biases based on the study design of included studies.
This study is still in preparation for launch. Once all analyses are complete, the results will be submitted for publication in a peer-reviewed journal.
This review will provide a clear and systematic metastatic pattern of colon cancer and evidence-based recommendations for the management of distant metastasis.
了解结肠癌的转移风险和模式对于患者评估和决策至关重要。然而，关于结肠癌转移的高质量证据尚缺。本研究旨在进行一项系统综述和荟萃分析，以确定特定部位转移的风险，并全面描绘结肠癌远处转移的情况。
本综述将纳入报告结肠癌患者不同部位转移比例的研究。符合条件的包括发表英文文章的临床试验、随访研究和横断面调查。我们将检索Medline、Embase、Web of Science和Cochrane图书馆，检索时间从建库至2023年6月。两名评审员将根据纳入标准独立筛选已识别记录的标题/摘要和全文。将提取符合条件研究的数据并用于荟萃分析。将进行荟萃分析以估计特定部位转移的总体比例。在荟萃分析期间，将分析两个比例，即转移发生率和构成比例。我们将根据纳入研究的设计选择合适的工具来评估偏倚风险。
本研究仍在筹备启动中。一旦所有分析完成，结果将提交至同行评审期刊发表。
本综述将提供清晰且系统的结肠癌转移模式，并为远处转移的管理提供循证建议。
