Callum Jack, Paik Julie, Hibbert Michael
Respiratory Department Royal North Shore Hospital Sydney NSW Australia.
Faculty of Medicine University of Queensland Brisbane QLD Australia.
Respirol Case Rep. 2021 Jan 19;9(2):e00703. doi: 10.1002/rcr2.703. eCollection 2021 Feb.
Appendiceal metastasis is a rare complication of primary lung cancer and an extremely rare cause of appendicitis. We present the case of a 62-year-old male who presented with right lower quadrant abdominal pain which revealed not only appendiceal inflammation, but also a lung mass and mediastinal lymph nodes. He then proceeded to appendicectomy and two days post-operatively an endobronchial ultrasound-guided biopsy. His mediastinal lymph node biopsy revealed a lung adenocarcinoma and his subsequent appendiceal immunohistochemistry revealed the same staining pattern for thyroid transcription factor 1 (TTF-1) and cytokeratin 7 (CK-7). We conducted a literature review which revealed 12 previous case reports of lung metastasis to the appendix causing appendicitis including three patients in whom appendicitis was the presenting complaint leading to lung cancer diagnosis. This case highlights the diversity of presentations for patients suffering from metastatic lung cancer.
阑尾转移是原发性肺癌的一种罕见并发症，也是阑尾炎极为罕见的病因。我们报告一例62岁男性病例，该患者表现为右下腹疼痛，检查发现不仅有阑尾炎症，还有肺部肿块和纵隔淋巴结。随后他接受了阑尾切除术，术后两天进行了支气管内超声引导下活检。他的纵隔淋巴结活检显示为肺腺癌，随后的阑尾免疫组化显示甲状腺转录因子1（TTF-1）和细胞角蛋白7（CK-7）的染色模式相同。我们进行了文献回顾，发现之前有12例关于肺转移至阑尾导致阑尾炎的病例报告，其中3例患者以阑尾炎为首发症状，最终确诊为肺癌。该病例突出了转移性肺癌患者临床表现的多样性。
