Al-Bayati Karam, Coneys Gerard, Cantor Michael, Gheorghe Rodica, Stone James K
Department of Internal Medicine, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
Department of Internal Medicine, Section of Gastroenterology, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
ACG Case Rep J. 2025 May 5;12(5):e01698. doi: 10.14309/crj.0000000000001698. eCollection 2025 May.
Esophageal epidermoid metaplasia (EEM) is a rare condition characterized by well-demarcated leukoplakia affecting the middle-to-distal esophagus. EEM commonly presents in middle-aged females with dysphagia and gastroesophageal reflux. EEM is thought to be associated with high-grade squamous dysplasia and squamous cell carcinoma. We report a case of a 63-year-old woman diagnosed with EEM after en bloc endoscopic submucosal dissection in a lesion initially reported as squamous dysplasia. The patient was initiated on a PPI with a 6-month follow-up showing no areas of squamous dysplasia or recurrent EEM with normal squamous mucosa on biopsy. The patient was symptom-free at 1-year follow-up.
食管表皮化生（EEM）是一种罕见疾病，其特征为食管中下段出现界限清晰的白斑。EEM常见于中年女性，伴有吞咽困难和胃食管反流。EEM被认为与高级别鳞状上皮发育异常和鳞状细胞癌有关。我们报告一例63岁女性病例，该患者最初病变被报告为鳞状上皮发育异常，经内镜下整块黏膜下剥离术后诊断为EEM。患者开始使用质子泵抑制剂（PPI）治疗，6个月随访时活检显示无鳞状上皮发育异常区域或复发性EEM，鳞状黏膜正常。1年随访时患者无症状。
