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克隆性扩散与结直肠癌的肿瘤异质性和不良预后相关。

Clonal dispersal is associated with tumor heterogeneity and poor prognosis in colorectal cancer.

作者信息

Baglamis Selami, Sheraton Vivek M, van Neerven Sanne M, Logiantara Adrian, Nijman Lisanne E, Hageman Laura A, Léveillé Nicolas, Elbers Clara C, Bijlsma Maarten F, Vermeulen Louis, Krawczyk Przemek M, Lenos Kristiaan J

机构信息

Amsterdam UMC, University of Amsterdam, Laboratory for Experimental Oncology and Radiobiology, 1081 BT Amsterdam, the Netherlands.

Cancer Center Amsterdam, Amsterdam, the Netherlands.

出版信息

iScience. 2025 Apr 10;28(5):112403. doi: 10.1016/j.isci.2025.112403. eCollection 2025 May 16.

DOI:10.1016/j.isci.2025.112403
PMID:40330878
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12051713/
Abstract

Clonal dispersal, resulting from the intermingling of tumor cell subpopulations, is thought to be a key driver of tumor heterogeneity. Despite advances in spatial modeling of cancer biology, quantification of clonal dispersal has been challenging. This study introduces a straightforward method, relying on fluorescent cell barcoding, to quantify clonal dispersal in various and models of colorectal cancer (CRC). Our approach allows for precise localization of clones and uncovering the degree of clonal mixing across different CRC models. Our findings suggest that clonal dispersal is correlated with the expression of genes involved in epithelial-mesenchymal transition and CMS4-related signaling pathways. We further identify a dispersal gene signature, associated with intratumor heterogeneity, which is a robust clinical predictor of poor prognosis and recurrence in CRC, highlighting its potential as a prognostic marker and a putative direction for therapeutic targeting.

摘要

肿瘤细胞亚群的混合导致的克隆性扩散被认为是肿瘤异质性的关键驱动因素。尽管癌症生物学的空间建模取得了进展，但克隆性扩散的量化一直具有挑战性。本研究引入了一种基于荧光细胞条形码的简单方法，以量化不同结直肠癌（CRC）模型中的克隆性扩散。我们的方法能够精确地定位克隆，并揭示不同CRC模型中克隆混合的程度。我们的研究结果表明，克隆性扩散与上皮-间质转化和CMS4相关信号通路中涉及的基因表达相关。我们进一步确定了一个与肿瘤内异质性相关的扩散基因特征，它是CRC预后不良和复发的有力临床预测指标，突出了其作为预后标志物的潜力以及治疗靶点的潜在方向。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5bb/12051713/d352a081eed5/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5bb/12051713/214f10e23f64/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5bb/12051713/ff5f50299043/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5bb/12051713/303ab48f884e/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5bb/12051713/6be12036976b/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5bb/12051713/d352a081eed5/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5bb/12051713/214f10e23f64/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5bb/12051713/ff5f50299043/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5bb/12051713/303ab48f884e/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5bb/12051713/6be12036976b/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5bb/12051713/d352a081eed5/gr4.jpg

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本文引用的文献

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Nat Commun. 2024 Sep 1;15(1):7609. doi: 10.1038/s41467-024-51424-4.
2
Prognostic genome and transcriptome signatures in colorectal cancers.结直肠癌的预后基因组和转录组特征。
Nature. 2024 Sep;633(8028):137-146. doi: 10.1038/s41586-024-07769-3. Epub 2024 Aug 7.
3
Simultaneously targeting extracellular vesicle trafficking and TGF-β receptor kinase activity blocks signaling hyperactivation and metastasis.
同时靶向细胞外囊泡转运和 TGF-β 受体激酶活性可阻断信号过度激活和转移。
Signal Transduct Target Ther. 2023 Dec 18;8(1):456. doi: 10.1038/s41392-023-01711-1.
4
Using picoliter droplet deposition to track clonal competition in adherent and organoid cancer cell cultures.利用皮升级液滴沉积技术追踪贴壁培养和类器官培养中的克隆竞争。
Sci Rep. 2023 Nov 1;13(1):18832. doi: 10.1038/s41598-023-42849-w.
5
High-Content and High-Throughput Clonogenic Survival Assay Using Fluorescence Barcoding.使用荧光条形码的高内涵和高通量克隆形成存活分析
Cancers (Basel). 2023 Sep 28;15(19):4772. doi: 10.3390/cancers15194772.
6
Role of Epithelial to Mesenchymal Transition in Colorectal Cancer.上皮-间质转化在结直肠癌中的作用
Int J Mol Sci. 2023 Oct 1;24(19):14815. doi: 10.3390/ijms241914815.
7
Unravelling the Complexity of Colorectal Cancer: Heterogeneity, Clonal Evolution, and Clinical Implications.解析结直肠癌的复杂性：异质性、克隆进化及临床意义
Cancers (Basel). 2023 Aug 8;15(16):4020. doi: 10.3390/cancers15164020.
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Int J Oncol. 2023 Mar;62(3). doi: 10.3892/ijo.2023.5486. Epub 2023 Feb 17.