Lim Sara N, Liu Yirong, Jawahar Anugayathri, Mittal Bharat B, Thomas Tarita O
Department of Radiation Oncology, Northwestern University Feinberg School of Medicine, 251 E Huron St, Chicago, IL 60611, USA.
Department of Diagnostic Radiology, Northwestern University Feinberg School of Medicine, 676 N St Clair St, Chicago, IL 60611, USA.
Phys Imaging Radiat Oncol. 2025 Apr 19;34:100768. doi: 10.1016/j.phro.2025.100768. eCollection 2025 Apr.
Trials have been performed on irradiating celiac plexus for pancreatic cancer pain management. Images from a combined magnetic resonance imaging and linear accelerator system (MR-linac) for ten patients were assessed for delineation of celiac ganglia, aiming for smaller target volumes and reducing treatment risks standard linac-based treatments. MRI-linacs showed superior soft tissue contrast, enabling increased dose to ganglia while irradiating smaller target volumes regular linacs (median: 0.8 cm vs. 32.2 cm, p < 0.05 for ten pairs of plans). While further studies are needed, MR-linac treatments could improve targeting precision, minimize dose to organs-at-risk and enhance effectiveness in palliative care.
已经开展了关于照射腹腔神经丛以管理胰腺癌疼痛的试验。对来自一个联合磁共振成像与直线加速器系统（MR直线加速器）的十名患者的图像进行评估，以确定腹腔神经节的轮廓，目标是缩小靶体积并降低治疗风险，与基于标准直线加速器的治疗方法相比。MR直线加速器显示出卓越的软组织对比度，在照射较小靶体积时能够增加对神经节的剂量，与常规直线加速器相比（中位数：0.8厘米对32.2厘米，十对计划的p < 0.05）。虽然还需要进一步研究，但MR直线加速器治疗可提高靶向精度，将对危及器官的剂量降至最低，并提高姑息治疗的有效性。
