• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Delites™补充剂可预防食用富含胆固醇和脂肪饮食的雄性斯普拉格-道利大鼠发生代谢综合征并调节肠道微生物群：一项随机临床前试验研究。

Delites™ supplementation prevents metabolic syndrome onset and modulates gut microbiome in male Sprague Dawley rats fed on cholesterol- and fat-enriched diet: a randomized preclinical trial study.

作者信息

Leonardo Juan, Hertanto Robby, Surya Reggie, Syahputra Rony Abdi, Humayrah Wardina, Sabrina Nindy, Taslim Nurpudji Astuti, Tallei Trina Ekawati, Tjandrawinata Raymond Rubianto, Nurkolis Fahrul

机构信息

Citra Deli Kreasitama Ltd., Banten, Indonesia.

Increase Laboratorium Indonesia, Biomedical Campus BSD City, Tangerang, Banten, Indonesia.

出版信息

Front Nutr. 2025 Apr 22;12:1571473. doi: 10.3389/fnut.2025.1571473. eCollection 2025.

DOI:10.3389/fnut.2025.1571473
PMID:40331097
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12052560/
Abstract

BACKGROUND

Metabolic syndrome (MetS) is a global health concern, characterized by a combination of dyslipidemia, insulin resistance, obesity, and hypertension, significantly increasing the risk of type 2 diabetes mellitus (T2DM) and cardiovascular diseases. Gut microbiota plays a pivotal role in MetS pathophysiology, with dysbiosis exacerbating metabolic impairments. Delites™, a supplement inspired by Traditional Chinese Medicine, has shown potential in modulating gut microbiota and mitigating MetS.

OBJECTIVES

This study aimed to evaluate the effects of Delites™ supplementation on metabolic health and gut microbiota composition in male Sprague Dawley rats fed a cholesterol- and fat-enriched diet (CFED).

METHODS

A randomized preclinical trial was conducted on 32 rats divided into four groups: control-normal, CFED, CFED+low-dose Delites™ (54 mg/kg), and CFED+high-dose Delites™ (108 mg/kg). Parameters including lipid profiles, enzymatic activity, molecular biomarkers, and gut microbiota composition were analyzed.

RESULTS

Delites™ significantly improved lipid profiles, reduced inflammation (TNF-), enhanced anti-inflammatory markers (IL-10), and increased energy metabolism regulator PGC-1α. Gut microbiota modulation showed increased beneficial genera (, ) and reduced pathogenic , improving microbial diversity.

CONCLUSION

Delites™ supplementation effectively mitigates MetS through metabolic and microbiota modulation. These findings highlight its potential for precision medicine approaches to combat metabolic disorders. Further research is needed to explore its long-term effects and translational relevance in humans.

摘要

背景

代谢综合征（MetS）是一个全球关注的健康问题，其特征为血脂异常、胰岛素抵抗、肥胖和高血压并存，显著增加了2型糖尿病（T2DM）和心血管疾病的风险。肠道微生物群在代谢综合征的病理生理过程中起关键作用，微生物群失调会加剧代谢障碍。Delites™是一种受传统中医启发研制的补充剂，已显示出调节肠道微生物群和减轻代谢综合征的潜力。

目的

本研究旨在评估补充Delites™对喂食高胆固醇和高脂肪饮食（CFED）的雄性Sprague Dawley大鼠代谢健康和肠道微生物群组成的影响。

方法

对32只大鼠进行随机临床前试验，分为四组：正常对照组、CFED组、CFED+低剂量Delites™（54mg/kg）组和CFED+高剂量Delites™（108mg/kg）组。分析了包括血脂谱、酶活性、分子生物标志物和肠道微生物群组成等参数。

结果

Delites™显著改善了血脂谱，减轻了炎症（TNF-），增强了抗炎标志物（IL-10），并增加了能量代谢调节因子PGC-1α。肠道微生物群调节显示有益菌属增加，致病菌减少，改善了微生物多样性。

结论

补充Delites™可通过调节代谢和微生物群有效减轻代谢综合征。这些发现突出了其在对抗代谢紊乱的精准医学方法中的潜力。需要进一步研究以探索其在人类中的长期影响和转化相关性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2cf/12052560/d97f05239c32/fnut-12-1571473-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2cf/12052560/119aef07d917/fnut-12-1571473-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2cf/12052560/490e7bbec1f8/fnut-12-1571473-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2cf/12052560/c80a1bb6f905/fnut-12-1571473-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2cf/12052560/703b631f8652/fnut-12-1571473-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2cf/12052560/11cac15f718b/fnut-12-1571473-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2cf/12052560/1d6bcf796eaf/fnut-12-1571473-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2cf/12052560/39c89e8eeeb3/fnut-12-1571473-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2cf/12052560/71743d9a44a6/fnut-12-1571473-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2cf/12052560/ee617f41ec51/fnut-12-1571473-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2cf/12052560/5c0507461a3c/fnut-12-1571473-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2cf/12052560/d97f05239c32/fnut-12-1571473-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2cf/12052560/119aef07d917/fnut-12-1571473-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2cf/12052560/490e7bbec1f8/fnut-12-1571473-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2cf/12052560/c80a1bb6f905/fnut-12-1571473-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2cf/12052560/703b631f8652/fnut-12-1571473-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2cf/12052560/11cac15f718b/fnut-12-1571473-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2cf/12052560/1d6bcf796eaf/fnut-12-1571473-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2cf/12052560/39c89e8eeeb3/fnut-12-1571473-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2cf/12052560/71743d9a44a6/fnut-12-1571473-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2cf/12052560/ee617f41ec51/fnut-12-1571473-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2cf/12052560/5c0507461a3c/fnut-12-1571473-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2cf/12052560/d97f05239c32/fnut-12-1571473-g011.jpg

相似文献

1
Delites™ supplementation prevents metabolic syndrome onset and modulates gut microbiome in male Sprague Dawley rats fed on cholesterol- and fat-enriched diet: a randomized preclinical trial study.Delites™补充剂可预防食用富含胆固醇和脂肪饮食的雄性斯普拉格-道利大鼠发生代谢综合征并调节肠道微生物群：一项随机临床前试验研究。
Front Nutr. 2025 Apr 22;12:1571473. doi: 10.3389/fnut.2025.1571473. eCollection 2025.
2
The total alkaloids of Berberidis Cortex alleviate type 2 diabetes mellitus by regulating gut microbiota, inflammation and liver gluconeogenesis.黄连总生物碱通过调节肠道菌群、炎症和肝脏糖异生缓解 2 型糖尿病。
J Ethnopharmacol. 2025 Jan 30;337(Pt 3):118957. doi: 10.1016/j.jep.2024.118957. Epub 2024 Oct 18.
3
Harnessing the Power of the Gut Microbiome: A Review of Supplementation Therapies for Metabolic Syndrome.利用肠道微生物群的力量：代谢综合征补充疗法综述
Cureus. 2024 Sep 18;16(9):e69682. doi: 10.7759/cureus.69682. eCollection 2024 Sep.
4
Renshen Zhuye decoction ameliorates high-fat diet-induced obesity and insulin resistance by modulating gut microbiota and metabolic homeostasis.人参竹叶汤通过调节肠道微生物群和代谢稳态改善高脂饮食诱导的肥胖和胰岛素抵抗。
Phytomedicine. 2025 Jun;141:156655. doi: 10.1016/j.phymed.2025.156655. Epub 2025 Mar 15.
5
Glycerol-Monolaurate-Mediated Attenuation of Metabolic Syndrome is Associated with the Modulation of Gut Microbiota in High-Fat-Diet-Fed Mice.甘油单月桂酸酯介导的代谢综合征衰减与高脂肪饮食喂养小鼠肠道微生物群的调节有关。
Mol Nutr Food Res. 2019 Sep;63(18):e1801417. doi: 10.1002/mnfr.201801417. Epub 2019 Aug 29.
6
Ligustrum robustum (Roxb.) blume extract modulates gut microbiota and prevents metabolic syndrome in high-fat diet-fed mice.女贞（Roxb.）提取物调节肠道微生物群，防止高脂肪饮食喂养的小鼠发生代谢综合征。
J Ethnopharmacol. 2021 Mar 25;268:113695. doi: 10.1016/j.jep.2020.113695. Epub 2020 Dec 13.
7
Short-chain fatty acids as a novel intervention for high-fat diet-induced metabolic syndrome.短链脂肪酸作为高脂饮食诱导的代谢综合征的一种新型干预措施。
Mol Cell Biochem. 2025 May;480(5):3169-3184. doi: 10.1007/s11010-024-05185-9. Epub 2024 Dec 21.
8
Whole mung bean (Vigna radiata L.) supplementation prevents high-fat diet-induced obesity and disorders in a lipid profile and modulates gut microbiota in mice.全绿豆（Vigna radiata L.）补充剂可预防高脂肪饮食引起的肥胖和脂质谱紊乱，并调节小鼠肠道微生物群。
Eur J Nutr. 2020 Dec;59(8):3617-3634. doi: 10.1007/s00394-020-02196-2. Epub 2020 Feb 11.
9
Ramulus Mori (Sangzhi) alkaloids ameliorate high-fat diet induced obesity in rats by modulating gut microbiota and bile acid metabolism.桑枝生物碱通过调节肠道微生物群和胆汁酸代谢改善高脂饮食诱导的大鼠肥胖。
Front Endocrinol (Lausanne). 2024 Dec 20;15:1506430. doi: 10.3389/fendo.2024.1506430. eCollection 2024.
10
PuRenDan alleviates type 2 diabetes mellitus symptoms by modulating the gut microbiota and its metabolites.朴仁丹通过调节肠道微生物群及其代谢物来缓解 2 型糖尿病症状。
J Ethnopharmacol. 2024 Mar 25;322:117627. doi: 10.1016/j.jep.2023.117627. Epub 2023 Dec 24.

本文引用的文献

1
The interplay of factors in metabolic syndrome: understanding its roots and complexity.代谢综合征中各因素的相互作用：了解其根源与复杂性。
Mol Med. 2024 Dec 27;30(1):279. doi: 10.1186/s10020-024-01019-y.
2
Treatment of Hypothalamic Obesity With GLP-1 Analogs.使用胰高血糖素样肽-1类似物治疗下丘脑性肥胖。
J Endocr Soc. 2024 Nov 14;9(1):bvae200. doi: 10.1210/jendso/bvae200. eCollection 2024 Nov 26.
3
Etiology, Pathophysiology, and Treatment Strategies in the Prevention and Management of Metabolic Syndrome.代谢综合征预防与管理中的病因、病理生理学及治疗策略
Arch Intern Med Res. 2024;7(4):273-283. doi: 10.26502/aimr.0184. Epub 2024 Oct 28.
4
Probiotics and Non-Alcoholic Fatty Liver Disease: Unveiling the Mechanisms of and in Modulating Lipid Metabolism, Inflammation, and Intestinal Barrier Integrity.益生菌与非酒精性脂肪性肝病：揭示益生菌在调节脂质代谢、炎症及肠道屏障完整性方面的机制
Foods. 2024 Sep 21;13(18):2992. doi: 10.3390/foods13182992.
5
Bifidobacterium and Lactobacillus Probiotics and Gut Dysbiosis in Preterm Infants: The PRIMAL Randomized Clinical Trial.双歧杆菌和乳杆菌益生菌与早产儿肠道菌群失调：PRIMAL 随机临床试验。
JAMA Pediatr. 2024 Oct 1;178(10):985-995. doi: 10.1001/jamapediatrics.2024.2626.
6
Gut Microbiota and Biomarkers of Intestinal Barrier Damage in Cirrhosis.肝硬化患者的肠道微生物群与肠道屏障损伤的生物标志物
Microorganisms. 2024 Feb 25;12(3):463. doi: 10.3390/microorganisms12030463.
7
Crosstalk between intestinal flora and human iron metabolism: the role in metabolic syndrome-related comorbidities and its potential clinical application.肠道菌群与人类铁代谢的相互作用：在代谢综合征相关合并症中的作用及其潜在的临床应用。
Microbiol Res. 2024 May;282:127667. doi: 10.1016/j.micres.2024.127667. Epub 2024 Mar 1.
8
A metagenomic alpha-diversity index for microbial functional biodiversity.一种用于微生物功能生物多样性的宏基因组 alpha 多样性指数。
FEMS Microbiol Ecol. 2024 Feb 14;100(3). doi: 10.1093/femsec/fiae019.
9
Sulfated Polysaccharide from Attenuates the Obesity-Induced Cardiometabolic Syndrome via Regulating the PRMT1-DDAH-ADMA with mTOR-SIRT1-AMPK Pathways and Gut Microbiota Modulation.来自[具体来源未给出]的硫酸化多糖通过mTOR-SIRT1-AMPK途径调节PRMT1-DDAH-ADMA以及调节肠道微生物群来减轻肥胖诱导的心脏代谢综合征。
Antioxidants (Basel). 2023 Aug 3;12(8):1555. doi: 10.3390/antiox12081555.
10
New Insights and Potential Therapeutic Interventions in Metabolic Diseases.代谢性疾病的新见解和潜在治疗干预。
Int J Mol Sci. 2023 Jun 26;24(13):10672. doi: 10.3390/ijms241310672.