Faculty of Sports Sciences, Universidad Europea de Madrid, Tajo Street, s/n, 28670 Madrid, Spain.
Grupo de Investigación en Cultura, Educación y Sociedad, Universidad de la Costa, Barranquilla 080002, Colombia.
Int J Mol Sci. 2023 Jun 26;24(13):10672. doi: 10.3390/ijms241310672.
Endocrine homeostasis and metabolic diseases have been the subject of extensive research in recent years. The development of new techniques and insights has led to a deeper understanding of the mechanisms underlying these conditions and opened up new avenues for diagnosis and treatment. In this review, we discussed the rise of metabolic diseases, especially in Western countries, the genetical, psychological, and behavioral basis of metabolic diseases, the role of nutrition and physical activity in the development of metabolic diseases, the role of single-cell transcriptomics, gut microbiota, epigenetics, advanced imaging techniques, and cell-based therapies in metabolic diseases. Finally, practical applications derived from this information are made.
近年来，内分泌稳态和代谢疾病一直是广泛研究的课题。新技术和新见解的发展使人们对这些疾病的发生机制有了更深入的了解，并为诊断和治疗开辟了新的途径。在这篇综述中，我们讨论了代谢疾病的兴起，特别是在西方国家，代谢疾病的遗传、心理和行为基础，营养和体育活动在代谢疾病发展中的作用，单细胞转录组学、肠道微生物群、表观遗传学、先进的成像技术和基于细胞的治疗在代谢疾病中的作用。最后，从这些信息中得出了实际应用。
