Key Laboratory of Basic Pharmacology and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi 563003, China.
Key Laboratory of Basic Pharmacology and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi 563003, China; Bioresource Institute for Healthy Utilization, Zunyi Medical University, Zunyi 563003, China.
Pharmacol Ther. 2024 Jul;259:108657. doi: 10.1016/j.pharmthera.2024.108657. Epub 2024 May 10.
Rosa roxburghii Tratt (RRT), known as chestnut rose, has been a subject of growing interest because of its diverse chemical composition and wide range of traditional uses. This comprehensive review aimed to thoroughly examine RRT, including its traditional applications, chemical diversity, and various bioactivities. The chemical profile of this plant is characterized by the presence of essential nutrients such as vitamin C (ascorbic acid), flavonoids, triterpenes, organic acids, tannins, phenolic compounds, polysaccharides, carotenoids, triterpenoids, volatile compounds, amino acids, and essential oils. These constituents contribute to the medicinal and nutritional value. Additionally, we explore the multifaceted bioactivities of RRT, including its potential as an anticancer agent, antioxidant, antiaging agent, antiatherogenic agent, hypoglycemic agent, immunoregulatory modulator, radioprotective agent, antimutagenic agent, digestive system regulator, anti-inflammatory agent, cardioprotective agent, and antibacterial agent, and its intriguing role in modulating the gut microbiota. Furthermore, we discuss the geographical distribution and genetic diversity of this plant species and shed light on its ecological significance. This comprehensive review provides a holistic understanding of RRT, bridges traditional knowledge with contemporary scientific research, and highlights its potential applications in medicine, nutrition, and pharmacology.
刺梨（Rosa roxburghii Tratt），又名茨梨、木梨子，因具有丰富的化学成分和广泛的传统用途而备受关注。本综述旨在全面研究刺梨，包括其传统应用、化学多样性和各种生物活性。该植物的化学特征是含有多种必需营养素，如维生素 C（抗坏血酸）、类黄酮、三萜、有机酸、单宁、酚类化合物、多糖、类胡萝卜素、三萜类化合物、挥发性化合物、氨基酸和精油。这些成分赋予了刺梨药用和营养价值。此外，我们还探讨了刺梨的多种生物活性，包括其作为抗癌剂、抗氧化剂、抗衰老剂、抗动脉粥样硬化剂、降血糖剂、免疫调节剂、放射保护剂、抗突变剂、消化系统调节剂、抗炎剂、心脏保护剂和抗菌剂的潜力，以及其在调节肠道微生物群方面的有趣作用。此外，我们还讨论了该植物物种的地理分布和遗传多样性，并阐明了其在生态系统中的重要意义。本综述全面地介绍了刺梨，将传统知识与当代科学研究相结合，并强调了其在医学、营养和药理学方面的潜在应用。
