男性酗酒者中血小板对血清素的摄取

Blood platelet uptake of serotonin in men alcoholics.

作者信息

Kent T A, Campbell J L, Pazdernik T L, Hunter R, Gunn W H, Goodwin D W

出版信息

J Stud Alcohol. 1985 Jul;46(4):357-9. doi: 10.15288/jsa.1985.46.357.

DOI:10.15288/jsa.1985.46.357

Abstract

Blood platelet uptake of 3H-serotonin (5HT uptake) was determined in a group of inpatient alcoholics who had just undergone detoxication (N = 19) and an age-matched group of nonalcoholic controls (N = 19). Mean 5HT uptake was 18% lower in the alcoholics (p less than .01). A 3-min 5HT uptake of less than 6 pmoles/10(7) platelets identified 58% of the alcoholics, but only 15% of the controls had a 5HT uptake lower than this value. These results support the hypothesis that serotonergic dysfunction may exist in alcoholics.

摘要

在一组刚完成脱毒治疗的住院酗酒者（N = 19）和一组年龄匹配的非酗酒对照组（N = 19）中，测定了血小板对³H - 5 - 羟色胺（5HT摄取）的摄取情况。酗酒者的平均5HT摄取量低18%（p < 0.01）。3分钟内5HT摄取量低于6皮摩尔/10⁷个血小板可识别出58%的酗酒者，但只有15%的对照组5HT摄取量低于此值。这些结果支持酗酒者可能存在血清素能功能障碍这一假说。