Golan Shekhtman Sapir, Beeri Michal Schnaider, Springer Ramit Ravona, Zadok Maya, Ben Meir Mery, Rosen-Lang Yael, Shutsberg Revital, Gelblum Dar, Niv Tal, Matatov Adar, Heymann Anthony, Azuri Joseph, Ganmore Ithamar, Hoffman Chen, Domachevsky Liran, Lesman-Segev Orit H
The Joseph Sagol Neuroscience Center, Sheba Medical Center, Ramat Gan, Israel.
Faculty of Medicine and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
Alzheimers Dement. 2025 May;21(5):e70115. doi: 10.1002/alz.70115.
Amyloid beta (Aβ) can be detected in vivo years before Alzheimer's disease (AD) symptom onset and, according to recent criteria, is sufficient for a biological diagnosis. This study evaluates emotional responses to Aβ status disclosure in cognitively normal individuals.
Questionnaires were given before and 6 months after Aβ positron emission tomography results disclosure to assess anxiety and depression related to the possibility of an elevated result, subjective memory complaints, and motivation for risk-reduction behavior.
One hundred ninety-nine cognitively normal adults were included. Non-elevated Aβ status disclosure was associated with reductions in all emotional parameters compared to baseline (p < 0.001). Elevated Aβ disclosure was associated with no changes in depression or memory complaints and a modest decrease in anxiety and motivation to change lifestyle (p < 0.048).
No negative psychological effects were observed after Aβ status disclosure. Decreased motivation for lifestyle changes was seen after disclosure of both elevated and non-elevated amyloid status and should be targeted.
No negative psychological effects were observed after amyloid beta (Aβ) status disclosure. Motivation for lifestyle changes decreased after Aβ disclosure. Lower education may predict "unfavorable" response to non-elevated Aβ disclosure. Results support personalized communication strategies for Aβ disclosure.
在阿尔茨海默病（AD）症状出现前数年就能在体内检测到β淀粉样蛋白（Aβ），并且根据最近的标准，这足以进行生物学诊断。本研究评估认知正常个体对Aβ状态披露的情绪反应。
在披露Aβ正电子发射断层扫描结果之前和之后6个月发放问卷，以评估与结果升高可能性相关的焦虑和抑郁、主观记忆抱怨以及降低风险行为的动机。
纳入了199名认知正常的成年人。与基线相比，未升高的Aβ状态披露与所有情绪参数降低相关（p < 0.001）。升高的Aβ披露与抑郁或记忆抱怨无变化以及焦虑和改变生活方式的动机适度降低相关（p < 0.048）。
Aβ状态披露后未观察到负面心理影响。在披露升高和未升高的淀粉样蛋白状态后，生活方式改变的动机均降低，应针对这一点。
β淀粉样蛋白（Aβ）状态披露后未观察到负面心理影响。Aβ披露后生活方式改变的动机降低。较低的教育程度可能预示对未升高的Aβ披露的“不利”反应。结果支持Aβ披露的个性化沟通策略。
