García-Aguilera María Fernanda, García-Méndez Nayely, Hernández Glenn, Fernández-Félix Borja M, Alexander-León Harold, Yu-Liu Yunqi, Rivadeneira Josue, Fuenmayor-González Luis, Robayo Cristopher Isaac Peña, Villalba Fernanda, Palacios Eduardo Andrés Aragundi, Borja Emérita Eugenia Basantes, Narvaez Henry Caballero, Alcocer Isabel Morales, Velazco Eduardo, Muñoz Georgina, Holguín-Carvajal Juan Pablo, Hernández Tamara Otzen, Manterola Carlos
Universidad de La Frontera - Temuco, Chile.
Faculty of Medical Sciences, Universidad Central del Ecuador - Quito, Ecuador.
Crit Care Sci. 2025 May 2;37:e20250283. doi: 10.62675/2965-2774.20250283. eCollection 2025.
This systematic review outlines a comprehensive approach to identify and analyze prognostic factors associated with mortality in adult cancer patients with sepsis in the intensive care unit. The review will focus on all-cause 28-day mortality, and where not available, we will use 30-day, intensive care unit, or in-hospital mortality.
We present a protocol for the systematic review of prognostic factors for mortality in adult cancer patients with sepsis managed in the intensive care unit. Our primary outcome is 28-day mortality, and where not available, we will use 30-day, intensive care unit, or in-hospital mortality. The secondary outcome is the global mortality incidence. Studies on the basis of the population (sepsis and neoplasms), prognostic study methods and outcome of interest (mortality) will be included. We will search the following databases: Medline, PubMed, EMBASE, SCOPUS, Web of Science, and Bireme-BVS, until April 5, 2024. The risk of bias will be assessed using the QUIPS tool. A meta-analysis will be conducted where possible to generate pooled estimates for identified prognostic factors. Two authors will independently assess the risk of bias in each study using the Quality in Prognostic Studies tool. The GRADE approach will be employed to evaluate the overall quality of evidence and the strength of the recommendations. Findings will be disseminated through publication in a peer-reviewed journal. This review aims to provide clinicians with valuable insights into factors influencing mortality risk in this high-risk population, ultimately informing clinical decision-making and improving patient outcomes.
The results of this review will be published in a peer-reviewed scientific journal. Does not require ethical approval.
本系统评价概述了一种全面的方法，用于识别和分析重症监护病房中成年癌症败血症患者与死亡率相关的预后因素。本评价将聚焦于全因28天死亡率，若该数据不可得，我们将使用30天、重症监护病房或住院死亡率。
我们提出了一项关于重症监护病房中成年癌症败血症患者死亡率预后因素系统评价的方案。我们的主要结局是28天死亡率，若该数据不可得，我们将使用30天、重症监护病房或住院死亡率。次要结局是总体死亡率发生率。将纳入基于人群（败血症和肿瘤）、预后研究方法以及感兴趣的结局（死亡率）的研究。我们将检索以下数据库：Medline、PubMed、EMBASE、SCOPUS、Web of Science和Bireme-BVS，检索截止至2024年4月5日。将使用QUIPS工具评估偏倚风险。将尽可能进行荟萃分析，以生成已识别预后因素的合并估计值。两位作者将使用预后研究质量工具独立评估每项研究的偏倚风险。将采用GRADE方法评估证据的总体质量和推荐强度。研究结果将通过在同行评审期刊上发表进行传播。本评价旨在为临床医生提供有关影响这一高危人群死亡风险因素的宝贵见解，最终为临床决策提供依据并改善患者结局。
本评价结果将发表在同行评审的科学期刊上。无需伦理批准。
